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Ca2+ administration stimulates the binding of AP-1 factor to the 5'-flanking region of the rat gene for the Ca2+-binding protein regucalcin.
The present study demonstrates that the Ca2+-response sequences are located within the 5'-flanking region of the rat regucalcin gene.
A Novel Isoform of Syntaxin-binding Protein Homologous to Yeast Sec1 Expressed Ubiquitously in Mammalian Cells (*)
Findings suggest that muSec1 is, via its binding to the syntaxin family, involved in the protein trafficking from the Golgi apparatus to the plasma membrane and that the fundamental mechanisms of protein trafficking have been conserved from yeast through virtually all mammalian cells.
Apoptosis inducing activity of 4‐substituted coumarins from Calophyllum brasiliense in human leukaemia HL‐60 cells
Results suggest that calophyllolide (2) and mammea B/BB (3) induced apoptosis in HL‐60 cells through activation of the caspase‐9/caspase-3 pathway, which is triggered by mitochondrial dysfunction.
Promoter Characterization of the Rat Gene for Ca2+-binding Protein Regucalcin
Results suggest that Bay K 8644-, dibutyryl cAMP-, phorbol ester-, and insulin-inducible nuclear factors mediate the stimulatory effect of each regulator on promoter activity of the rat regucalcin gene.
Induction of apoptosis by isoflavonoids from the leaves of Millettia taiwaniana in human leukemia HL-60 cells.
The results suggest that the isoflavonoids induced apoptosis in HL-60 cells through activation of the caspase-9/caspased-3 pathway, which is triggered by mitochondrial dysfunction.
Quinolone alkaloids with nitric oxide production inhibitory activity from Orixa japonica.
Four new quinolone alkaloids, orixalone A (1), B (2), C (3), and D (4), together with 12 known compounds were isolated from the stems of Orixa japonica. Orixalone A (1) inhibited nitric oxide
Methyl galbanate, a novel inhibitor of nitric oxide production in mouse macrophage RAW264.7 cells
It is shown that methyl galbanate protected neuronally differentiated tsAM5NE cells from NO-induced cell death by inhibiting the production of NO, suggesting that methyl Galbanate may be useful for developing a new drug against neurodegenerative diseases.
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro
It is suggested that regucalcin may play a potential role as a suppressor of human lung cancer, and that downregulation of regucaalcin expression may predispose patients to development of lung cancer.