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Structure of the Rotor of the V-Type Na+-ATPase from Enterococcus hirae
The membrane rotor ring from the vacuolar-type (V-type) sodium ion–pumping adenosine triphosphatase (Na+-ATPase) from Enterococcus hirae consists of 10 NtpK subunits, which are homologs of the…
Structural Basis of Biological N2O Generation by Bacterial Nitric Oxide Reductase
The transmembrane region topology and arrangement of metal centers in NOR are similar to those in cytochrome oxidases, key enzymes in aerobic respiration, and a structural comparison gives insight into the features that allow conversion between nitric oxide and oxygen reduction.
G protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
The raising of a mouse monoclonal antibody against human A2AAR that prevents agonist but not antagonist binding to the extracellular ligand-binding pocket is reported and results suggest a new strategy to modulate the activity of G-protein-coupled receptors.
Structure and mechanism of the mammalian fructose transporter GLUT5
It is shown that a single point mutation is enough to switch the substrate-binding preference of GLUT5 from fructose to glucose, and local asymmetric rearrangements of carboxy-terminal transmembrane bundle helices TM7 and TM10 underlie a ‘gated-pore’ transport mechanism in such monosaccharide transporters.
Crystal structures of the human adiponectin receptors
The present information will facilitate the understanding of novel structure–function relationships and the development and optimization of AdipoR agonists for the treatment of obesity-related diseases, such as type 2 diabetes.
PhoPQ-Mediated Regulation Produces a More Robust Permeability Barrier in the Outer Membrane of Salmonella enterica Serovar Typhimurium
- T. Murata, W. Tseng, T. Guina, Samuel I. Miller, H. Nikaido
- BiologyJournal of bacteriology
- 10 August 2007
It is found that the remodeling process in PhoP-constitutive strains produces an outer membrane that serves as a very effective permeability barrier in an environment that is poor in divalent cations or that contains cationic peptides, whereas its absence in phoP null mutants produces anouter membrane severely compromised in its barrier function under these conditions.
Crystal structure of the anion exchanger domain of human erythrocyte band 3
The crystal structure of the transmembrane anion exchanger domain of AE1 is reported, which includes 14 trans Membrane helices and provides a basis for understanding the effects of mutations that lead to red blood cell diseases and also gives insight into the mechanism of ion transport.
On the mechanism of substrate specificity by resistance nodulation division (RND)‐type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in…
It is suggested that the precise structure of the periplasmic loops of MexD determines the rate of transport of individual substrates, consistent with the hypothesis that, in the case of RND transporters, the LPLs are directly implicated in substrate recognition and contain multiple sites of interaction for various structurally diverse compounds.
Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures
These asymmetric structures represent the first high-resolution view of the rotational mechanism of V1-ATPase from the A3B3 and DF complexes and suggest a binding order in the right-handed rotational orientation in a cooperative manner.
Substrate-Dependent Utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK Efflux Pump
- R. Chuanchuen, T. Murata, N. Gotoh, H. Schweizer
- Biology, EngineeringAntimicrobial Agents and Chemotherapy
- 1 May 2005
This is the first report of natural utilization of multiple OMPs by a given resistance nodulation cell division transporter/membrane fusion protein pair.