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Isolation, Biochemical and Molecular Identification, and In-Vitro Antimicrobial Resistance Patterns of Bacteria Isolated from Bubaline Subclinical Mastitis in South India
High resistance of the associated bacteria to the β-lactam class of antibiotics, and a possible major role of coagulase-negative staphylococci in causing the disease in India are revealed.
Evaluation of the immunogenicity of the P97R1 adhesin of Mycoplasma hyopneumoniae as a mucosal vaccine in mice.
- Austen Y. Chen, S. Fry, J. Forbes-Faulkner, G. Daggard, T. Mukkur
- Biology, MedicineJournal of medical microbiology
- 1 July 2006
It is suggested that live bacterial vectors carrying DNA vaccines or expressing heterologous antigens preferentially induce a Th1 response, and the importance of assessing the suitability of attenuated S. typhimurium aroA harbouring either expression system is emphasized.
Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide.
The effect of methylmercury, tetraethyl lead, and sodium arsenite on the humoral immune response in mice.
Development of improved vaccines against whooping cough: Current status
- Ibrahim Marzouqi, P. Richmond, S. Fry, J. Wetherall, T. Mukkur
- Medicine, BiologyHuman vaccines
- 1 July 2010
The epidemiology of whooping cough is described, the vast array of virulence factors produced by this pathogen potentially contributing to the resurgence of pertussis even in previously vaccinated populations of infants and children are described, and possible mechanisms of immunity and lack of availability of a suitable non-toxic adjuvant capable of inducing both arms of the immune response are described.
Evaluation of immune response to recombinant potential protective antigens of Mycoplasma hyopneumoniae delivered as cocktail DNA and/or recombinant protein vaccines in mice.
Diversity of Virulence Factors Associated with West Australian Methicillin-Sensitive Staphylococcus aureus Isolates of Human Origin
Using RAPD-PCR for determining the virulence factor-based genetic relatedness among the isolates revealed five cluster groups confirming genetic diversity among the MSSA isolates, with the greatest majority of the clinical S. aureus isolates clustering in group IIIa.
Protection against experimental salmonellosis in mice and sheep by immunisation with aromatic-dependent Salmonella typhimurium.
Sheep immunised with the live mutant strain by either the intramuscular or oral route were protected against oral challenge with the virulent ovine isolate of S. typhimurium; unimmunised sheep died of acute enteritis within 7 days, although there was no evidence of systemic invasion by the challenge organism.
Rapid-Cycle PCR Method To Detect Bordetella pertussis That Fulfills All Consensus Recommendations for Use of PCR in Diagnosis of Pertussis
- D. Farrell, M. McKeon, G. Daggard, M. Loeffelholz, C. J. Thompson, T. Mukkur
- Biology, MedicineJournal of Clinical Microbiology
- 1 December 2000
A rapid (4 h, including specimen preparation) PCR method which fulfills all of the consensus recommendations was developed and validated for the detection of B. pertussis.
Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance
- Dorji Dorji, F. Mooi, O. Yantorno, R. Deora, R. Graham, T. Mukkur
- Biology, MedicineMedical Microbiology and Immunology
- 1 February 2018
The potential roles of different accredited virulence factors, including novel biofilm-associated antigens, of B. pertussis in the evolution, formulation and delivery of improved pertussedis vaccines, with potential to block the transmission of whooping cough in the community are discussed.