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Methanolic extract of Pereskia bleo (Kunth) DC. (Cactaceae) induces apoptosis in breast carcinoma, T47-D cell line.
TLDR
The results from this study strongly suggest that the methanol extract of Pereskia bleo may contain bioactive compound(s) that caused breast carcinoma, T-47D cell death by apoptosis mechanism via the activation of caspase-3 and c-myc pathways. Expand
Programmed Cell Death Pathways and Current Antitumor Targets
TLDR
This review aims to discuss the most recent antitumor strategies targeting the apoptosis and autophagy signaling pathways and the latest outcome of clinical trials of the above drugs. Expand
Effect of dietary HUFA on reproductive performance, tissue fatty acid profile and desaturase and elongase mRNAs in female swordtail Xiphophorus helleri
TLDR
It was showed that female swordtail benefits from inclusion of dietary HUFA during reproductive stages, despite possessing the ability to increase transcription of desaturase and elongase during low dietary H UFA provision, however, excessive dietaryHUFA could result in imbalanced ratios of HU FA, which could impair reproductive processes. Expand
Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth.
TLDR
The findings indicate the major role of 3,4-di-O-caffeoyl quinic acid to antioxidant capacities of Elephantopus mollis extracts and is thus a promising non toxic agent in treating cancer and type 2 diabetes mellitus. Expand
Growth arrest and non-apoptotic programmed cell death associated with the up-regulation of c-myc mRNA expression in T-47D breast tumor cells following exposure to Epipremnum pinnatum (L.) Engl.
TLDR
It is suggested that up-regulation of c-myc mRNA expression may have contributed to the growth arrest and Type II non-apoptotic programmed cell death in the Epipremnum pinnatum (L.) Engl. Expand
Andrographolide and 14-deoxy-11, 12-didehydroandrographolide inhibit cytochrome P450s in HepG2 hepatoma cells.
TLDR
These diterpenoids are potential CYP3A4 inhibitors and the effects on CYP1A2, CYP2D6, and CYP 3A4 may be clinically significant. Expand
Interleukin-6 inhibition of peroxisome proliferator-activated receptor alpha expression is mediated by JAK2- and PI3K-induced STAT1/3 in HepG2 hepatocyte cells
TLDR
This study has unraveled novel pathways by which IL-6 inhibits PPAR α gene transcription, involving the modulation of JAK2/STAT1–3 and PI3K/AKT/mTOR by inducing the binding of STAT1 and STAT3 to STAT-binding sites on the PPARα promoter. Expand
The PPARgamma coding region and its role in visceral obesity.
TLDR
This review may help investigate the differential expression of key transcription factor in adipose tissue in response to visceral obesity-induced diet in vivo and provide valuable information to define a more appropriate physiological condition in adipogenesis. Expand
Cloning and characterization of poly(3‐hydroxybutyrate) biosynthesis genes from Pseudomonas sp. USM 4‐55
TLDR
Three open reading frames encoding NADPH‐dependent acetoacetyl‐coenzyme A reductase, β‐ketothiolase and P(3HB) synthase were found in the phb operon and showed a putative promoter region, followed by phbBPs‐ phbAPs‐phbCPs. Expand
Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease
TLDR
A new tetracyclic merosesquiterpene was isolated from the marine sponge Hyrtios digitatus along with the known 20-methoxy-9,15-ene-puupehenol, and their structures were elucidated on the basis of spectroscopic data (1H and 13C NMR) in combination with experimental electronic circular dichroism (ECD) data. Expand
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