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Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease
Streptococcus agalactiae is a commensal bacterium colonizing the intestinal tract of a significant proportion of the human population. However, it is also a pathogen which is the leading cause ofExpand
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CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in Gram‐positive bacteria
clpP and clpC of Bacillus subtilis encode subunits of the Clp ATP‐dependent protease and are required for stress survival, including growth at high temperature. They play essential roles inExpand
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CovS/CovR of group B streptococcus: a two‐component global regulatory system involved in virulence
In this study, we carried out a detailed structural and functional analysis of a Streptococcus agalactiae (GBS) two‐component system which is orthologous to the CovS/CovR (CsrS/CsrR) regulatoryExpand
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ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation
The nucleotide sequence of the Bacillus subtilis clpP gene was determined. The predicted protein shows very high similarity to members of the ClpP family of proteolytic subunits (68% amino acidExpand
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Bacitracin and nisin resistance in Staphylococcus aureus: a novel pathway involving the BraS/BraR two‐component system (SA2417/SA2418) and both the BraD/BraE and VraD/VraE ABC transporters
Two‐component systems (TCSs) are key regulatory pathways allowing bacteria to adapt their genetic expression to environmental changes. Bacitracin, a cyclic dodecylpeptide antibiotic, binds toExpand
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Identification of genes controlled by the essential YycG/YycF two-component system of Staphylococcus aureus.
The YycG/YycF essential two-component system (TCS), originally identified in Bacillus subtilis, is very highly conserved and appears to be specific to low-G+C gram-positive bacteria, includingExpand
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The phosphorylation state of the DegU response regulator acts as a molecular switch allowing either degradative enzyme synthesis or expression of genetic competence in Bacillus subtilis.
Two classes of mutations were identified in the degS and degU regulatory genes of Bacillus subtilis, leading either to deficiency of degradative enzyme synthesis (degS or degU mutations) or to aExpand
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Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus
The Hsp100/Clp ATPases constitute a family of closely related proteins of which some members function solely as chaperones whereas others additionally can associate with the unrelated ClpP peptidaseExpand
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A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway
The WalK/WalR (aka YycG/YycF) two‐component system (TCS), originally identified in Bacillus subtilis, is very highly conserved and specific to low G+C Gram‐positive bacteria, including a number ofExpand
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Genes controlled by the essential YycG/YycF two‐component system of Bacillus subtilis revealed through a novel hybrid regulator approach
The YycG/YycF two‐component system, originally identified in Bacillus subtilis, is very highly conserved and appears to be specific to low G + C Gram‐positive bacteria. This system is required forExpand
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