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Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report.
Antithrombotic therapy for venous thromboembolic disease.
Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study.
Major types of PH had characteristic distribution patterns of obstructive intimal lesions, showing mainly a myofibroblastic phenotype and variable endothelial/vascular differentiation.
The diagnostic approach to acute venous thromboembolism. Clinical practice guideline. American Thoracic Society.
Optimizing prevention of hospital-acquired venous thromboembolism (VTE): prospective validation of a VTE risk assessment model.
Improved VTE prophylaxis resulted in a substantial reduction in HA VTE and prospectively validated a VTE risk-assessment/prevention protocol by demonstrating ease of use, good interobserver agreement, and effectiveness.
Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension.
Findings suggest that endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension, which is attenuated by theendothelin receptor antagonist, bosentan.
Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis.
- T. Morris, J. Marsh, P. Chiles, W. Auger, P. Fedullo, Virgil L. Woods
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 1 June 2006
The persistence of structural motifs of fibrin, such as the beta-chain N-terminus, within the pulmonary vasculature could promote the transition from acute thromboemboli into chronic obstructive vascular scars.
Pulmonary embolism during and after pregnancy
Objective testing is critical to establish the diagnosis of venous thromboembolic disease and can be safely performed during pregnancy, but patients may be transitioned to warfarin after delivery.
Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry.
Analysis of the dysfibrinogen Bβ 235 Pro/Leu, which exhibits abnormal fibrin structure, revealed enhanced deuterium exchange surrounding the Pro/ Leu substitution site as well as in the vicinity of the high affinity calcium binding site and the A knob polymerization pocket within the γC domain.
Noninvasive Diagnosis of Venous Thromboembolism
- T. Morris
The principles of each test are discussed, and the diagnostic criteria are explained and critiqued, and promising newer strategies are described that may enable VTE to be diagnosed faster, easier, and less expensively.