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Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis.
BACKGROUND/AIMS Matrix metalloproteinase (MMP)-1 and MMP-3 have important roles in the connective tissue remodelling and destruction processes in periodontitis. MMP-1 1G/2G (-1607) and MMP-3 5A/6AExpand
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Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue.
Background: The balance between the degradation and synthesis of extracellular matrix determines periodontal attachment levels and alveolar bone matrix concentration in periodontal diseases. MatrixExpand
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Smoking cessation increases gingival blood flow and gingival crevicular fluid.
OBJECTIVES The purpose of the present study was to determine the effect of smoking cessation on gingival blood flow (GBF) and gingival crevicular fluid (GCF). MATERIAL AND METHODS Sixteen maleExpand
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Elevated mRNA expression for supervillin and vascular endothelial growth factor in human neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis.
Differential gene expression was examined in human neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis (P. gingivalis-LPS) using RNA fingerprinting by arbitrarily primedExpand
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Alterations of gene expression in human neutrophils induced by smoking cessation.
OBJECTIVE The purpose of the present study was to investigate the effect of smoking cessation on the peripheral neutrophil mRNA expression levels for inflammatory cytokines, chemokine, growth factorExpand
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Effects of irrigation with an antiseptic and oral administration of azithromycin on bacteremia caused by scaling and root planing.
BACKGROUND Transient bacteremia frequently occur secondary to several periodontal procedures. The purpose of the present study is to investigate the effects of irrigation with an essentialExpand
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Amyloid beta (A4) precursor protein expression in human periodontitis-affected gingival tissues.
OBJECTIVE Periodontitis involves periodontal tissue destruction and is associated with chronic inflammation and ageing. Periodontitis has recently been recognised as a risk factor for Alzheimer'sExpand
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Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues.
BACKGROUND AND OBJECTIVE Gene expression is related to the pathogenesis of periodontitis and plays a crucial role in local tissue destruction and disease susceptibility. The aims of the present studyExpand
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Differential gene expression in neutrophils from patients with generalized aggressive periodontitis.
Differential gene expression was investigated in neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine using RNA fingerprinting by arbitrarily primed polymerase chain reactionExpand
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Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study.
BACKGROUND AND OBJECTIVE A diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. The aim of this multicenter study wasExpand
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