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Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production.
Th1 and Th2 cells are different from each other in early activation signal transduction pathways, especially in the role of protein tyrosine kinases, according to the results. Expand
YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models.
The inhibition of Ca(2+) influx through CRAC channel leads to the prevention of antigen-induced airway inflammation, probably via the inhibition of Th2 cytokine production and inflammatory mediators release, and YM-58483 may therefore be useful for treatingAirway inflammation in bronchial asthma. Expand
C57BL/6 mice are more susceptible to antigen‐induced pulmonary eosinophilia than BALB/c mice, irrespective of systemic T helper 1/T helper 2 responses
Results indicate that C57BL/6 mice induce Th2‐type responses in the lungs, while BALB/c mice induce T helper 1 (Th1)‐ type responses inThe lungs, despite considerable production of IL‐4 and IL‐5 from splenocytes. Expand
Mechanism of enhanced antigen presentation by B cells activated with anti‐μ plus interferon‐γ: Role of B7‐2 in the activation of naive and memory CD4+ T cells
It is suggested that IFN‐γ plays an important role in recruitment of naive T cells for an immune response in response to antigen presentation by B cells activated by anti‐μ plus IFN'γ. Expand
Mechanisms of Donor‐Specific Tolerance in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation
It is demonstrated that T cell recovery is gradual and is characterized by memory‐type cell predominance and an increased proportion of CD4+CD25+CD127−FOXP3+ Treg during the lymphopenic period, and long‐term tolerance appears to be maintained by a deletion or anergy mechanism. Expand
Antigen dose defines T helper 1 and T helper 2 responses in the lungs of C57BL/6 and BALB/c mice independently of splenic responses.
To investigate the effect of antigen dose on immune response, C57BL/6 and BALB/c mice were sensitized with aluminum hydroxide gel (alum)-precipitated ovalbumin (OVA) then challenged with aerosolizedExpand
Effect of a novel anti-inflammatory compound, YM976, on antigen-induced eosinophil infiltration into the lungs in rats, mice, and ferrets.
YM976 is a promising drug for the treatment of diseases involving eosinophil activity, such as asthma, and its anti-inflammatory activity in ferrets suggested that the compound exhibits a considerable dissociation between itsAnti-inflammatory and emetic effects. Expand
Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney–Bone Marrow Transplantation to Induce Transplantation Tolerance
Examination of tolerance mechanisms in patients receiving HLA‐mismatched combined kidney–bone marrow transplantation that led to transient chimerism under a previously published nonmyeloablative conditioning regimen suggests enrichment of Tregs by new thymic emigration and lymphopenia‐driven peripheral proliferation in the early posttransplantation period may contribute to tolerance after CKBMT. Expand
In vitro and in vivo characterization of a novel CCR3 antagonist, YM-344031.
YM-344031 has potential as a novel and orally available compound for the treatment of allergic inflammation, such as atopic dermatitis and asthma, through inhibition of Eotaxin-1/CCR3 interaction. Expand
Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor.
Results indicate that YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-3-dimethoxy-6, 6-dimethyl-5,6-dihydrobenzo[7,8]indolizino [2,3-b]quinoxaline to the IL- 5 receptor (IL-5R). Expand