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Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon
TLDR
The effects of all the components of White's medium on the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon were investigated and Nitrate, phosphate, copper, sulfate and sucrose had especially marked effects. Expand
Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon
TLDR
The yield of derivatives increased with an increase in the carbon chain length of the n-paraffin used as the solvent and when the oxygen supply was sufficient it reached the value found for the ordinary culture method. Expand
High density culture of Coptis japonica cells increases berberine production
A high density culture method was devised to improve the yield of berberine from highly productive cells of Coptis japonica. By adjusting aeration and stirring, Coptis cells were cultured atExpand
Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon. III. Comparison of shikonin derivatives of cultured cells and ko-shikon
TLDR
The composition of shikonin derivatives produced by cell suspension cultures was similar to that of the ko-shikon, and the composition in cultured cells was found to fluctuate less than that ofThe ko-Shikon. Expand
Flow Cytometric Analysis of Cellular Berberine Contents in High- and Low-Producing Cell Lines of Coptis japonica Obtained by Repeated Selection.
Cell lines that were highly productive for berberine were selected by repeated cloning of small cell aggregates. The berberine content of the highest-producing cell line increased after 4 clonings toExpand
Enhancement of Berberine Production in Suspension Cultures of Coptis japonica by Gibberellic Acid Treatment
TLDR
The results suggest that the change in the incorporation rate of main nutrients triggered by gibberellic acid has a marked effect on the synthesis and accumulation of berberine. Expand
Semisynthetic Production of Vinblastine Involving Cell Cultures of Catharanthus Roseus and Chemical Reaction
Vinblastine (VLB) is a rare dimeric alkaloid contained in Catharanthus roseus and used in treating leukemia and malignant lymphoma. Many researchers have studied the production of VLB by plant cellExpand
Berberine Production by Cultured Coptis japonica Cells in a One-stage Culture Using Medium with a High Copper Concentration
Berberine is an important phytochemical known to have antibacterial, stomachic and anti-inflammatory activities. The rhizome of a typical source plant, Coptisjaponica, has a low content ofberberineExpand
Effect of gibberellic acid on berberine and tyrosine accumulation in Coptis japonica
TLDR
It is proposed that GA 3 treatment contributes to berberine production by activating primary metabolic steps involved in tyrosine biosynthesis. Expand
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