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New mammalian expression vectors
The RNA polymerases from T7 and related bacteriophages, in conjunction with elements of DNA and RNA viruses, can be used in novel ways for expression of genes in mammalian cells.
Identification of cell-active lysine specific demethylase 1-selective inhibitors.
TLDR
The first small-molecule LSD1-selective inhibitors are identified and show in vivo H3K4-methylating activity and antiproliferative activity and should be useful as lead structures for anticancer drugs and as tools for studying the biological roles of LSD1. Expand
Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product.
TLDR
GEX1A serves as a novel splicing inhibitor that specifically impairs the SF3b function by binding to SAP155 protein, a subunit ofSF3b responsible for pre-mRNA splicing. Expand
Cloning and expression of cDNA for salmon growth hormone in Escherichia coli.
TLDR
Mature sGH was efficiently expressed in Escherichia coli carrying a plasmid in which the sGH cDNA was under control of the E. coli trp promoter; sGH comprised about 15% of the total cellular protein in such bacteria. Expand
G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma
TLDR
Results suggest that G1-phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitors p21 and p27. Expand
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
TLDR
Findings suggest that combination treatment with JMJD2 inhibitors and LSD1 inhibitors may represent a novel strategy for anticancer chemotherapy. Expand
The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1
TLDR
The data identify a novel pathway through which N-Myc causes neuroblastoma cell migration and invasion, and provide important evidence for further development of more potent JMJD1A/MALAT1 inhibitors for the prevention of tumor metastasis. Expand
Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.
TLDR
Compound 6j, which selectively inhibits JARID1A over three other JHDM family members, and compound 7j synergistically enhanced A549 human lung cancer cell growth inhibition induced by vorinostat, a histone deacetylase inhibitor support the idea that JARIDs1A inhibitors have potential as anticancer agents. Expand
Identification of ryuvidine as a KDM5A inhibitor
TLDR
Ryuvidine may serve as a lead compound for KDM5 targeted therapeutics after it was found that ryuvidine prevented generation of gefitinib-tolerant human small-cell lung cancer PC9 cells and also inhibited the growth of the drug-Tolerant cells at concentrations that did not affect thegrowth of parentalPC9 cells. Expand
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