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Protein phosphatases 1 and 2A are both required for long‐term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo
Evidence shows that the serine/threonine protein phosphatase 1 (PP1) plays a critical role in synaptic plasticity and memory. Little is known about the contribution of the serine/threonineExpand
Protein kinase C involvement in homologous desensitization of delta- opioid receptor coupled to Gi1-phospholipase C activation in Xenopus oocytes
We have developed the coexpression system of both delta-opioid receptor (DOR1) and M2-muscarinic receptor (M2) which mediate agonist-evoked currents due to common post-receptor mechanisms includingExpand
Non-effective dose of exogenously applied l-DOPA itself stereoselectively potentiates postsynaptic D2 receptor-mediated locomotor activities of conscious rats
We attempted to clarify whether or not under inhibition of central dopa decarboxylase non-effective i.p. doses of L-dopa potentiate D2 receptor-mediated locomotor activities without conversion toExpand
Distinct Physiological Maturation of Parvalbumin-Positive Neuron Subtypes in Mouse Prefrontal Cortex
Parvalbumin-positive (PV+) neurons control the timing of pyramidal cell output in cortical neuron networks. In the prefrontal cortex (PFC), PV+ neuron activity is involved in cognitive function,Expand
Cholinergic modulation of neuronal excitability and recurrent excitation‐inhibition in prefrontal cortex circuits: implications for gamma oscillations
•  Previous studies indicate that cholinergic neuromodulation is required for cognitive processes and for gamma oscillatory activity in neocortical networks in vivo. The cholinergic agonist carbacholExpand
δ Opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes
Cloned mouse δ‐subtype opioid receptor (DOR1) was expressed in Xenopus oocytes to study the signal transduction. Opioid δ‐agonists evoked a calcium‐dependent chloride current in oocytes injected withExpand
Postsynaptic diacylglycerol lipase α mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex
Non‐Technical Summary  In multiple brain regions, endogenous cannabinoids suppress inhibitory synaptic transmission; however, the biochemical/molecular pathways for endocannabinoid synthesis areExpand
A Seven-Transmembrane Receptor That Mediates Avoidance Response to Dihydrocaffeic Acid, a Water-Soluble Repellent in Caenorhabditis elegans
The ability to detect harmful chemicals rapidly is essential for the survival of all animals. In Caenorhabditis elegans (C. elegans), repellents trigger an avoidance response, causing animals to moveExpand
Opioid μ- and κ-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes
Abstract In the Xenopus oocytes expressing μ or κ-opioid receptors, agonist-induced currents were observed only when the oocyte was coinjected with Gi1 α RNA and pretreated with K-252a, a potentExpand
LTP‐ and LTD‐inducing stimulations cause opposite changes in arc/arg3.1 mRNA level in hippocampal area CA1 in vivo
Immediate early genes (IEGs) typically are the first genetic responders to a variety of cellular activations. The IEG that encodes activity‐regulated cytoskeleton‐associated protein (arc/arg3.1) hasExpand