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Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India.
TLDR
Even though there was no association between the individuals carrying the variant genotypes of the three miRNA studied and bladder cancer risk, marginal significance of heterozygousity in rs11614913 suggested further characterization of miRNA SNPs in a large cohort of varied ethnicity.
Role of functional polymorphisms of P53 and P73 genes with the risk of prostate cancer in a case-control study from Northern India.
TLDR
Evidence is provided that the P53 intron 6 G>A and R72P G>C polymorphisms were associated with a higher risk of prostate cancer in a Northern Indian population.
Frequencies of VKORC1 -1639 G>A, CYP2C9*2 and CYP2C9*3 genetic variants in the Northern Indian population.
TLDR
The VKORC1 -1639 G>A allele is present at moderately high frequency in the Northern Indian population and the frequencies of CYP2C9*2 and CYP9*3 alleles are also found to be different from other populations.
Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients.
TLDR
MMP9 R668Q plays important role in conferring susceptibility of LVD in coronary artery disease patients and was significantly associated with LVD (LVEF ≤ 45).
Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.
TLDR
The data suggests that NFKB1 -94 ATTG ins/del polymorphism plays significant role in conferring susceptibility of LVD and ATTG/ATTG genotype may modulate risk of heart failure by increasing ventricular remodeling and worsening LV function.
Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians.
TLDR
This study provided new support for the association of DR4 and Casp3, 5 in BC development, the tumorigenic effect of which was observed to be more enhanced in case of smoking exposure.
Therapeutic Dosing of Acenocoumarol: Proposal of a Population Specific Pharmacogenetic Dosing Algorithm and Its Validation in North Indians
TLDR
An efficient north India specific pharmacogenetic acenocoumarol dosing algorithm is proposed which might become a baseline for personalised medicine approach for treatment of patients in future.
Impact of Renin-Angiotensin-Aldosterone System Gene Polymorphisms on Left Ventricular Dysfunction in Coronary Artery Disease Patients
TLDR
AT1 A1166C plays important role in conferring susceptibility of LVD through association of single nucleotide polymorphisms in angiotensin I converting enzyme and aldosterone synthase with LVD.
CYP4F2 1347 G>A & GGCX 12970 C>G polymorphisms: frequency in north Indians & their effect on dosing of acenocoumarol oral anticoagulant
Background & objectives: CYP4F2 and γ-glutamyl carboxylase (GGCX) have small but significant roles in the maintenance dose of coumarinic oral anticoagulants (COAs). CYP4F2 1347 G>A and GGCX 12970 C>G
Association of 25 bp Deletion in MYBPC3 Gene with Left Ventricle Dysfunction in Coronary Artery Disease Patients
TLDR
The frequency of MYBPC3 DW genotype and D allele was associated with compromised LVEF implying that genetic variants of myosin binding protein C encoding mutant structural sarcomere protein could increase susceptibility to left ventricular dysfunction.
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