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Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure.
TLDR
In dogs with HF, acute intravenous administration of the pFOX inhibitor ranolazine improves LV systolic function and suggests that the drug is devoid of any positive inotropic effects and acts primarily by optimizing cardiac metabolism in the setting of chronic HF. Expand
Effects of Long-Term Monotherapy With Eplerenone, a Novel Aldosterone Blocker, on Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Heart Failure
TLDR
It is indicated that long-term therapy with eplerenone prevents progressive LV dysfunction and attenuates LV remodeling in dogs with chronic HF. Expand
Intraventricular dyssynchrony may play a role in the development of mitral regurgitation in dilated cardiomyopathy.
TLDR
Dyssynchrony of myocardial segments adjacent to the papillary muscles may disturb synchronized closure of the mitral leaflets and cause MR in DCM. Expand
Reverse remodeling and enhanced adrenergic reserve from passive external support in experimental dilated heart failure.
TLDR
Reverse remodeling with reduced systolic wall stress and improved adrenergic signaling can be achieved by passive external support that does not generate diastolic constriction, and may prove useful in the treatment of chronic heart failure. Expand
Passive epicardial containment prevents ventricular remodeling in heart failure.
TLDR
In dogs with heart failure, passive epicardial containment of the ventricles with the Acorn CSD ameliorates LV remodeling and improves LV systolic function. Expand
Reversal of Chronic Molecular and Cellular Abnormalities Due to Heart Failure by Passive Mechanical Ventricular Containment
TLDR
The results suggest that preventing LV dilation and stretch with the CSD promotes downregulation of stretch response proteins, attenuates myocyte hypertrophy and improves SR calcium cycling. Expand
Reduced sarcoplasmic reticulum Ca(2+)-uptake and expression of phospholamban in left ventricular myocardium of dogs with heart failure.
TLDR
It is concluded that SR Ca(2+)-uptake and SR PLB and CAA protein and gene expression levels are reduced in LV myocardium of dogs with chronic HF, which can lead to Ca( 2+)-overload and subsequent global LV dysfunction. Expand
A manikin-based observational study on cardiopulmonary resuscitation skills at the Osaka Senri medical rally.
TLDR
The ERC guidelines were more rational and suitable in terms of actual application than the AHA guidelines as demonstrated at the 2006 and 2007 Osaka Senri medical rallies. Expand
Effects of Dopamine β-Hydroxylase Inhibition With Nepicastat on the Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Chronic Heart Failure
TLDR
A randomized, blinded, placebo-controlled investigation of the long-term effects of therapy with the DBH inhibitor nepicastat (NCT) on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Expand
Effects of long-term therapy with bosentan on the progression of left ventricular dysfunction and remodeling in dogs with heart failure.
TLDR
In dogs with moderate HF, long-term therapy with bosentan prevents the progression of LV dysfunction and attenuates LV chamber remodeling and the findings support the use of mixed endothelin-1 receptor antagonists as adjuncts to the long- term treatment of HF. Expand
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