• Publications
  • Influence
Pharmacokinetic study of a tripeptide HIV‐1 protease inhibitor, KNI‐174, in rats after intravenous and intraduodenal administrations
TLDR
An HPLC assay system is developed and examined the pharmacokinetics of KNI‐174 in rats using this assay method after both intravenous and intraduodenal administrations to obtain the disposition characteristics and bioavailability of this new anti‐AIDS drug.
Comparison of a new orally potent tripeptide HIV‐1 protease inhibitor (anti‐aids drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations
TLDR
Although the anti‐AIDS virus activity of these two drugs has not been investigated in vivo, KNI‐272 is expected to be a better candidate for oral anti-AIDS therapies.
Synthesis and biological evaluation of a 13N-labeled opioid peptide.
A synthetic method suitable for the rapid preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62).
TLDR
A synthetic method suitable for the preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62), was established and the time profile of the radioactivity accumulation in the brain paralleled well that of the analgesic activity.