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How host-microbial interactions shape the nutrient environment of the mammalian intestine.
Humans and other mammals are colonized by a vast, complex, and dynamic consortium of microorganisms. One evolutionary driving force for maintaining this metabolically active microbial society is toExpand
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Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: a Cross-Sectional Study
ABSTRACT A cross-sectional study on intestinal microbiota composition was performed on 230 healthy subjects at four European locations in France, Germany, Italy, and Sweden. The study participantsExpand
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A Model of Host-Microbial Interactions in an Open Mammalian Ecosystem
The maintenance and significance of the complex populations of microbes present in the mammalian intestine are poorly understood. Comparison of conventionally housed and germ-free NMRI mice revealedExpand
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A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem.
Little is known about how members of the indigenous microflora interact with their mammalian hosts to establish mutually beneficial relationships. We have used a gnotobiotic mouse model to show thatExpand
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Creating and Maintaining the Gastrointestinal Ecosystem: What We Know and Need To Know from Gnotobiology
SUMMARY Studying the cross talk between nonpathogenic organisms and their mammalian hosts represents an experimental challenge because these interactions are typically subtle and the microbialExpand
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Paneth cell differentiation in the developing intestine of normal and transgenic mice.
Paneth cells represent one of the four major epithelial lineages in the mouse small intestine. It is the only lineage that migrates downward from the stem-cell zone located in the lower portion ofExpand
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Manipulating the gut microbiota to maintain health and treat disease
Abstract Background: The intestinal microbiota composition varies between healthy and diseased individuals for numerous diseases. Although any cause or effect relationship between the alterations inExpand
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Short-chain fatty acids in germfree mice and rats.
The short-chain fatty acids (SCFAs) have been analyzed in small intestinal and cecal content of 10 germfree and six conventional mice from a Norwegian laboratory, in cecal content and serum of fiveExpand
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Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite.
Denitrifying bacteria in soil generate nitric oxide (NO) from nitrite as a part of the nitrogen cycle, but little is known about NO production by commensal bacteria. We used a chemiluminescence assayExpand
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The relevance of gene transfer to the safety of food and feed derived from genetically modified (GM) plants.
In 2000, the thematic network ENTRANSFOOD was launched to assess four different topics that are all related to the testing or assessment of food containing or produced from genetically modifiedExpand
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