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The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
The gene corresponding to the S. cerevisiae cell division cycle mutant cdc25 has been cloned and sequenced, revealing an open reading frame encoding a protein of 1589 amino acids that contains no… Expand
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
- G. Bolger, T. Michaeli, +6 authors K. Ferguson
- Biology, Medicine
- Molecular and cellular biology
- 1 October 1993
We have isolated cDNAs for four human genes (DPDE1 through DPDE4) closely related to the dnc learning and memory locus of Drosophila melanogaster. The deduced amino acid sequences of the Drosophila… Expand
The Calcium/Calmodulin-dependent Phosphodiesterase PDE1C Down-regulates Glucose-induced Insulin Secretion*
- P. Han, J. Werber, M. Surana, N. Fleischer, T. Michaeli
- Biology, Medicine
- The Journal of Biological Chemistry
- 6 August 1999
To understand the role cAMP phosphodiesterases (PDEs) play in the regulation of insulin secretion, we analyzed cyclic nucleotide PDEs of a pancreatic β-cell line and used family and isozyme-specific… Expand
A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies.
STUDY QUESTION Is thin endometrium unresponsive to standard treatments expandable by intrauterine perfusion with granulocyte colony-stimulating factor (G-CSF)? SUMMARY ANSWER This cohort study is… Expand
PDE7A1, a cAMP-specific Phosphodiesterase, Inhibits cAMP-dependent Protein Kinase by a Direct Interaction with C*
- P. Han, Pushpalatha Sonati, C. Rubin, T. Michaeli
- Chemistry, Medicine
- Journal of Biological Chemistry
- 2 June 2006
The N-terminal regulatory region of the high affinity cAMP-specific phosphodiesterase, PDE7A1, contains two copies of the cAMP-dependent kinase (PKA) pseudosubstrate site RRGAI. In βTC3 insulinoma… Expand
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.
- T. Michaeli, T. J. Bloom, +6 authors M. Wigler
- Medicine, Biology
- The Journal of biological chemistry
- 15 June 1993
We have established a highly sensitive functional screen for the isolation of cDNAs encoding cAMP phosphodiesterases (PDEs) by complementation of defects in a Saccharomyces cerevisiae strain lacking… Expand
GNP1, the high-affinity glutamine permease of S. cerevisiae
Abstract Glutamine uptake in S. cerevisiae is mediated by at least three transporters: high- and low-affinity glutamine permeases and the general amino-acid permease. We have isolated the gene… Expand
MSI1 suppresses hyperactive RAS via the cAMP-dependent protein kinase and independently of chromatin assembly factor-1
RAS hyperactivation in the yeast Saccharomyces cerevisiae leads to multiple nutritional growth defects associated with overstimulation of the cAMP signaling pathway. Hyperactive RAS can be suppressed… Expand
Alternative Splicing of the High Affinity cAMP-Specific Phosphodiesterase (PDE7A) mRNA in Human Skeletal Muscle and Heart*
To further our understanding of the structure and function of phosphodiesterases of the newly identified family of high affinity cAMP-specific phosphodiesterases (PDE7), we identified and… Expand
Studies of RAS function in the yeast Saccharomyces cerevisiae.
- M. Wigler, J. Field, +7 authors Kenneth Ferguson
- Biology, Medicine
- Cold Spring Harbor symposia on quantitative…
The three mammalian RAS genes, Ha-ras, Ki-ras, and N-ras, are capable of the malignant transformation of cultured animal cells (Barbacid 1987). Mutations in these genes have been linked to a large… Expand