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Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.
Several systems-level datasets designed to dissect host-pathogen interactions during influenza A infection have been reported. However, apparent discordance among these data has hampered their fullExpand
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Qualimap: evaluating next-generation sequencing alignment data
MOTIVATION The sequence alignment/map (SAM) and the binary alignment/map (BAM) formats have become the standard method of representation of nucleotide sequence alignments for next-generationExpand
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Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
Influenza A virus, being responsible for seasonal epidemics and reoccurring pandemics, represents a worldwide threat to public health. High mutation rates facilitate the generation of viral escapeExpand
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  • Open Access
Robust Salmonella metabolism limits possibilities for new antimicrobials
New antibiotics are urgently needed to control infectious diseases. Metabolic enzymes could represent attractive targets for such antibiotics, but in vivo target validation is largely lacking. HereExpand
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Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction
The obligate intracellular bacterium Chlamydia trachomatis survives and replicates within a membrane-bound vacuole, termed the inclusion, which intercepts host exocytic pathways to obtain nutrients.Expand
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Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
Infection with the human microbial pathogen Helicobacter pylori is assumed to lead to invasive gastric cancer. We find that H. pylori activates the hepatocyte growth factor/scatter factor receptorExpand
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  • Open Access
Autodisplay: one-component system for efficient surface display and release of soluble recombinant proteins from Escherichia coli.
The immunoglobulin A protease family of secreted proteins are derived from self-translocating polyprotein precursors which contain C-terminal domains promoting the translocation of the N-terminallyExpand
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Genome‐wide analysis of transcriptional hierarchy and feedback regulation in the flagellar system of Helicobacter pylori
Summary The flagellar system of Helicobacter pylori, which comprises more than 40 mostly unclustered genes, is essential for colonization of the human stomach mucosa. In order to elucidate theExpand
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Src Is the Kinase of the Helicobacter pylori CagA Protein in Vitro and in Vivo *
The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes phosphorylated onExpand
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  • Open Access