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Vesicular Glutamate Transporter VGLUT2 Expression Levels Control Quantal Size and Neuropathic Pain
Uptake of l-glutamate into synaptic vesicles is mediated by vesicular glutamate transporters (VGLUTs). Three transporters (VGLUT1–VGLUT3) are expressed in the mammalian CNS, with partial overlappingExpand
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Novel Role for Vascular Endothelial Growth Factor (VEGF) Receptor-1 and Its Ligand VEGF-B in Motor Neuron Degeneration
Although vascular endothelial growth factor-B (VEGF-B) is a homolog of the angiogenic factor VEGF, it has only minimal angiogenic activity, raising the question of whether this factor has other (moreExpand
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Role of 5-HT2 receptors in the tryptamine-induced 5-HT syndrome in rats
We distinguished the functions of the different 5-hydroxytryptamine-2 (5-HT2) receptor (5-HT2R) subtypes in the tryptamine-induced 5-HT syndrome in rats using (1) the 5-HT2AR antagonist R93274Expand
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Sustained synchronized neuronal network activity in a human astrocyte co-culture system
Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative disorders such as autism, schizophrenia, and Alzheimer’s disease and is typically studied usingExpand
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Functional study of rat 5‐HT2A receptors using antisense oligonucleotides
We studied the effects in rats of a 6‐day intracerebroventricular (i.c.v) infusion of four different end‐capped phosphorothioate‐modified antisense oligonucleotides (AOs), specifically targetingExpand
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Automatic colorimetric calibration of human wounds
BackgroundRecently, digital photography in medicine is considered an acceptable tool in many clinical domains, e.g. wound care. Although ever higher resolutions are available, reproducibility isExpand
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Neuronal FLT1 receptor and its selective ligand VEGF‐B protect against retrograde degeneration of sensory neurons
Even though VEGF‐B is a homologue of the potent angiogenic factor VEGF, its angiogenic activities have been controversial. Intrigued by findings that VEGF‐B may also affect neuronal cells, weExpand
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A Comparison of the Antinociceptive and Adverse Effects of the μ-Opioid Agonist Morphine and the δ-Opioid Agonist SNC80
: delta-Opioid receptor agonists have been postulated to induce analgesia without the adverse effects commonly associated with mu-opioids e.g. morphine. In the present study, we evaluated theExpand
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Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy.
Systemic vascular endothelial growth factor inhibition, in combination with chemotherapy, improves the outcome of patients with metastatic cancer. Peripheral sensory neuropathies occurring inExpand
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