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Ex vivo cell labeling with 64Cu–pyruvaldehyde-bis(N4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography
TLDR
Results indicate that in vivo imaging of cell trafficking is possible with 64Cu–PTSM-labeled cells and given the longer t1/2 of 64Cu relative to 18F, longer cell-tracking periods should be possible now with PET. Expand
Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model.
TLDR
Cu-ATSM exhibits selectivity for hypoxic tumor tissue both in vivo and in vitro and may provide a successful diagnostic modality for the detection of tumor ischemia. Expand
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel
TLDR
A database consisting of 62 PET ligands that have successfully reached the clinic and 15 radioligands that failed in late-stage development as negative controls was built, which identified a set of preferred parameters for physicochemical properties, brain permeability, and nonspecific binding. Expand
The reactivity of selected acrylate esters toward glutathione and deoxyribonucleosides in vitro: structure-activity relationships.
TLDR
Structural-activity relationships for reactivity of selected esters with glutathione (GSH) and deoxyribonucleosides were investigated and acrylate electrophilic reactivity decreased with alpha-methyl substitution; however, the decrease was more evident in the cell-free system than in the red blood cell model. Expand
Localization of oviductal glycoproteins within the zona pellucida and perivitelline space of ovulated ova and early embryos in baboons (Papio anubis).
TLDR
Results indicate that baboon estrogen-dependent oviductal secretory glycoproteins become intimately associated with ovidUCTal ova and with embryos. Expand
In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET
TLDR
Findings demonstrate that quantitative evaluation of islet β-cell density and aggregate BCM can be performed clinically with 18F-FP-(+)-DTBZ PET, a promising target for BCM imaging in type 1 diabetes mellitus. Expand
In Vivo Assessment and Dosimetry of 2 Novel PDE10A PET Radiotracers in Humans: 18F-MNI-659 and 18F-MNI-654
TLDR
PET imaging in the human brain with 2 novel PDE10A 18F tracers is being reported, with good agreement between the Logan and simplified reference tissue models for nondisplaceable binding potential (BPND), supporting noninvasive quantification. Expand
N,N'-ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III): molecular modeling, thermodynamic stability and in vivo studies.
TLDR
A molecular mechanics evaluation of the Ga- and In-EC complexes support the thermodynamic results and derivatives of EC may have applications as bifunctional chelates for 111In-labeled proteins and peptides. Expand
A NEW SPECIES OF CHOCOAN STURNIRA (CHIROPTERA: PHYLLOSTOMIDAE: STENODERMATINAE) FROM WESTERN ECUADOR AND COLOMBIA
ABSTRACT A distinctive new species of sturnirine bat, Sturnira (Sturnira) koopmanhilli, new species (Chiroptera: Phyllostomidae: Stenodermatinae), is described from 49 specimens collected in theExpand
Kinetic Modeling of the Serotonin 5-HT1B Receptor Radioligand [11C]P943 in Humans
TLDR
The results show that [11C]P943 provides quantitative measurements of 5-HT1B binding potential, and the MRTM2 model provided the best correlation with MA1 binding-potential estimates. Expand
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