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Mouse-human chimeric anti-Tn IgG1 induced anti-tumor activity against Jurkat cells in vitro and in vivo.
- H. Ando, T. Matsushita, +5 authors S. Ohta
- Biology, MedicineBiological & pharmaceutical bulletin
- 1 September 2008
Results suggest that humanized antibody against clustered Tn-antigens is a promising therapeutic antibody against TN-positive cancers.
Novel anti-Tn single-chain Fv-Fc fusion proteins derived from immunized phage library and antibody Fc domain.
- T. Kubota, T. Matsushita, Rinpei Niwa, I. Kumagai, K. Nakamura
- Biology, MedicineAnticancer research
- 1 September 2010
The scFv-Fcs obtained here showed strict specificity against the Tn antigen and also showed antibody-dependent cellular cytotoxicity, suggesting a potential use of this antibody generating method by phage display and indicating the potential of Fc-fusion proteins as therapeutic candidates.
Engineered therapeutic antibodies with enhanced effector functions: Clinical application of the Potelligent® Technology
- T. Matsushita
- MedicineThe Korean journal of hematology
- 1 September 2011
The Potelligent® Technology is provided, which has been most extensively tested in clinical trials, and is thought to be one of the most promising and practical approaches to make an antibody more efficacious.