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p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
The data indicate that this Nrf2 inhibitor could be used to make cancer cells less resistant to anticancer drugs, especially in HCV-positive HCC patients.
Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives.
Ipso substitution of bisphenol A catalyzed by microsomal cytochrome P450 and enhancement of estrogenic activity.
Substituent elimination from p-substituted phenols by cytochrome P450. ipso-Substitution by the oxygen atom of the active species.
- T. Ohe, T. Mashino, M. Hirobe
- Chemistry, BiologyDrug metabolism and disposition: the biological…
Experiments using 18O2 proved that the elimination is accompanied with ipso-substitution by the oxygen atom of the active species in cytochrome P450, and indicated that the mechanism of the substituent elimination can be divided into two types: the substitUent is eliminated as an anion or as a cation.
Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin.
Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.
An HPLC assay of hydroxyl radicals by the hydroxylation reaction of terephthalic acid.
An HPLC assay for hydroxyl radicals is described, and theHydroxyl radical formed in the Fenton reaction was successfully assayed in the concentration range of hydrogen peroxide of 2.5-50 micro mol/L, where the concentration of Fe(II) was 50 micromol/L.
Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276.
alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme.
Superoxide radical initiates the autoxidation of dihydroxyacetone.