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Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.
It is shown that a conserved N-terminal domain of HTH directly binds to EXD in vitro, and is sufficient to induce the nuclear localization ofEXD in vivo, however, mutating a key DNA binding residue in the HTH homeodomain abolishes many of its in vivo functions. Expand
Characterization of anillin mutants reveals essential roles in septin localization and plasma membrane integrity
Anillin is a conserved component of the contractile ring that is essential for cytokinesis, and physically interacts with three conserved cleavage furrow proteins, F-actin, myosin II and septins in… Expand
An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo
It is demonstrated that punt, like tkv, is essential in vivo for dpp-dependent patterning processes and that both receptors act in concert to transduce the dpp signal and that their functions cannot be replaced by the other extant type II and I receptors. Expand
Nuclear interpretation of Dpp signaling in Drosophila
A complex interplay between the nuclear factors involved in Dpp signaling appears to control the transcriptional readout of the Dpp morphogen gradient, which remains to be seen whether similar molecular mechanisms operate in the nucleus in vertebrate systems. Expand
Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans
- C. Couwenbergs, J. Labbé, Morgan B. Goulding, T. Marty, B. Bowerman, M. Gotta
- Biology, Medicine
- The Journal of cell biology
- 8 October 2007
It is found that the depletion of dyrb-1 enhances the spindle positioning defect of weak loss of function alleles of two regulators of G protein signaling, LIN-5 and GPR-1/2, and that DYRB-1 physically associates with these two proteins. Expand
Schnurri mediates Dpp-dependent repression of brinker transcription
It is shown that Schnurri (Shn), a large zinc-finger protein, is essential for Dpp-mediated repression of brk transcription; in contrast, Shn is not required for target-gene activation, which bifurcates, downstream of the signal-mediating SMAD proteins, into a Shn-dependent pathway leading to brk repression and aShn-independent pathway lead to gene activation. Expand
Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc.
Drosophila cyclin E (DmcycE) protein is absent in G1 phase cells but appears at the onset of S phase in proliferating cells of the larval optic lobe and eye imaginal disc, providing evidence for additional regulatory mechanisms that operate during G 1 phase to limit cell proliferation during development. Expand
A HOX complex, a repressor element and a 50 bp sequence confer regional specificity to a DPP-responsive enhancer.
- T. Marty, M. Vigano, C. Ribeiro, U. Nussbaumer, N. C. Grieder, M. Affolter
- Biology, Medicine
- 15 July 2001
A detailed characterization of an enhancer that is regulated by DPP signaling and by the homeotic protein Labial and its partners, Extradenticle and Homothorax is undertaken, finding that the inducibility of this lab550 enhancer is weak because it is tuned down by the action of a repressor element. Expand
Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling
- N. C. Grieder, T. Marty, H. Ryoo, R. Mann, M. Affolter
- Biology, Medicine
- The EMBO journal
- 15 December 1997
It is shown that LAB and EXD bind cooperatively to the site in vitro, and that the expression of the enhancer in vivo requires exd and lab function, suggesting that EXD and LAB bind to this site in vivo. Expand
Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13.
A trans-species analysis of the cis-regulatory region of ceh-13, the worm ortholog of the Drosophila labial and the vertebrate Hox1 genes, finds that the molecular mechanisms that regulate its expression may be similar to what has been found in species that follow a regulative, non-cell-autonomous mode of development. Expand