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SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses
TLDR
A unique mechanism of SNARE motif-dependent endocytic sorting is unraveled and the ANTH domain proteins AP180 and CALM are identified as cargo-specific adaptors for synaptobrevin endocytosis. Expand
Clathrin/AP-2 Mediate Synaptic Vesicle Reformation from Endosome-like Vacuoles but Are Not Essential for Membrane Retrieval at Central Synapses
TLDR
It is shown that clathrin and its major adaptor protein 2 (AP-2) in addition to the plasma membrane operate at internal endosome-like vacuoles to regenerate SVs but are not essential for membrane retrieval. Expand
Chloride channel diseases resulting from impaired transepithelial transport or vesicular function.
TLDR
This review will focus on diseases related to transepithelial transport and on disorders involving vesicular Cl- channels, including muscle disorder myotonia, cystic fibrosis, renal salt loss in Bartter syndrome, kidney stones, deafness, and the bone disease osteopetrosis. Expand
Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission
TLDR
It is demonstrated that loss of the Syb 2-specific endocytic adaptor AP180 causes a moderate activity-dependent reduction of vesicular Syb2 levels, defects in SV reformation, and a corresponding impairment of neurotransmission that lead to excitatory/inhibitory imbalance, epileptic seizures, and premature death. Expand
Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2
TLDR
It is demonstrated that deletion of the endocytic adaptor stonin 2 (Stn2) in mice compromises the fidelity of SV protein sorting, whereas the apparent speed of SV retrieval is increased. Expand
Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex
TLDR
The data provide a direct molecular link between TGN-derived EVs and the microtubule-based cytoskeleton and suggest that the role of Gadkin as a regulator of endosomal membrane traffic critically depends on complex formation with both AP-1 and KIF5. Expand
Modes and mechanisms of synaptic vesicle recycling
TLDR
Accumulating evidence further suggests that SV membrane retrieval and the reformation of functional SVs are separable processes that may allow synapses to rapidly restore membrane surface area over a wide range of stimulations followed by slow reforming of release-competent SVs. Expand
Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity*
TLDR
It is shown that COH1 is a peripheral Golgi membrane protein that strongly co-localizes with the cis-Golgi matrix protein GM130 and is established as a Golgi-associated matrix protein required for Golgi integrity. Expand
Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
TLDR
It is shown that in neurons, autophagosomes promote neuronal complexity and prevent neurodegeneration in vivo via retrograde transport of brain-derived neurotrophic factor (BDNF)-activated TrkB receptors via endocytic adaptor AP-2, an essential protein complex previously thought to function exclusively in clathrin-mediated endocytosis. Expand
Neurogenic Mechanisms Contribute to Hypertension in Mice With Disruption of the K-Cl Cotransporter KCC3
TLDR
The data indicate that local control of myogenic tone does not require KCC3 and that hypertension in Kcc3−/− mice depends on an elevated sympathetic tone, and a neurogenic component in the maintenance of this phenotype is demonstrated. Expand
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