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Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni.
There is a pressing need to develop novel anti-schistosomal drugs, as current treatment relies largely on praziquantel (PZQ). To further strengthen current evidence of the anti-schistosomal… Expand
Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro.
- J. Keiser, T. Manneck, M. Vargas
- Biology, Medicine
- The Journal of antimicrobial chemotherapy
- 1 August 2011
OBJECTIVES Mefloquine has interesting antischistosomal properties, hence it might be an attractive partner drug for combination treatment with praziquantel. The aim of this study was to evaluate… Expand
Schistosoma mansoni: antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo.
Recent studies have shown that mefloquine (MQ) reveals interesting antischistosomal properties. We examined the antischistosomal activities of the erythro and threo isomers and racemates of MQ on… Expand
Isothermal Microcalorimetry To Study Drugs against Schistosoma mansoni
- T. Manneck, O. Braissant, Y. Haggenmüller, Jennifer Keiser
- Biology, Medicine
- Journal of Clinical Microbiology
- 26 January 2011
ABSTRACT Alternative antischistosomal drugs are required since praziquantel is virtually the only drug available for treatment and morbidity control of schistosomiasis. Manual microscopic reading is… Expand
Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase.
The antimalarial drug mefloquine has promising antischistosomal properties killing haematophagous adult schistosomes as well as schistosomula. The mode of action and involved drug targets of… Expand
Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica.
- J. Keiser, T. Manneck, C. Kirchhofer, O. Braissant
- Medicine, Biology
- Experimental parasitology
- 1 March 2013
Isothermal microcalorimetry (IMC) is an analytical tool that continuously measures the heat flow generated by chemical, physical or biological processes. We have demonstrated that IMC is a useful… Expand
Antischistosomal properties of Mefloquine : from in vitro studies to drug target discovery
- T. Manneck
Schistosomiasis is a chronic helminthic disease caused by fluke worms of the genus Schistosoma spp. The disease belongs to the so-called neglected tropical diseases (NTDs) and is endemic in… Expand