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Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10.
Two sublines of a breast epithelial cell culture, MCF-10, derived from human fibrocystic mammary tissue exhibit immortality after extended cultivation in low calcium concentrations (0.03-0.06 mM) andExpand
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Transformation of Human Breast Epithelial Cells by c‐Ha‐ras Oncogene
To determine whether the c‐Ha‐ras oncogene plays a role in the initiation of mammary carcinogenesis, an immortalized human breast epithelial cell line, MCF‐10A, was transfected with the plasmidExpand
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Combination chemotherapy (CMFVP) versus L‐phenylalanine mustard (L‐PAM) for operable breast cancer with positive axillary nodes. A southwest oncology group study
The Southwest Oncology Group in a prospective randomized study compared one year of adjuvant combination chemotherapy with continuous CMFVP to two years of intermittent L‐PAM in women with operableExpand
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Evidence for a direct growth-stimulating effect of estradiol on human MCF-7 cells in vivo.
The MCF-7 continuous line of human breast cancer cells requires that athymic nude mice receive supplemental estrogen so that inocula can produce progressively growing tumors. Although these cellsExpand
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Adjuvant CMFVP versus melphalan for operable breast cancer with positive axillary nodes: 10-year results of a Southwest Oncology Group Study.
Four hundred forty-one women with operable breast cancer with histologically positive axillary nodes were randomized to receive either combination cyclophosphamide (60 mg/m2 orally everyday for 1Expand
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Lack of benefit of adjunctive chemotherapy in stage I malignant melanoma: a Southwest Oncology Group Study.
In 1975, the Southwest Oncology Group initiated an adjuvant study in localized malignant melanoma testing the value of aggressive chemotherapy using carmustine, hydroxyurea, and dacarbazine versus aExpand
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Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study.
Combination induction chemotherapy consisting of vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) was administered to 126 patients with advanced germ cell tumors of the testis. FollowingExpand
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Vinblastine, bleomycin and cis-diamminedichloroplatinum in disseminated testicular cancer: response to treatment and prognostic correlations. A Southwest Oncology Group Study.
Abstract One-hundred and forty-three patients with advanced germinal cell neoplasms of the testis were treated with a 4-month induction chemotherapy regimen of vinblastine, bleomycin and cisExpand
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Bilateral breast cancer: one disease or two?
Our purpose was to determine whether bilateral breast cancer depends upon genetic predisposition to multiple tumors or, alternatively, represents two independent sporadic events. BiologicalExpand
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Synthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs.
Radio-labeled somatostatin analogs have recently gained popularity as agents useful in intraoperative tumor localization, external scintigraphy and in situ radiotherapy. We have synthesized andExpand
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