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Finding the missing heritability of complex diseases
Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture.Expand
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The Drosophila melanogaster Genetic Reference Panel
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability toExpand
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Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines.
The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring geneticExpand
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The genetic architecture of quantitative traits.
  • T. Mackay
  • Biology, Medicine
  • Annual review of genetics
  • 1 December 2001
Phenotypic variation for quantitative traits results from the segregation of alleles at multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and externalExpand
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The genetics of quantitative traits: challenges and prospects
A major challenge in current biology is to understand the genetic basis of variation for quantitative traits. We review the principles of quantitative trait locus mapping and summarize insights aboutExpand
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Systems Genetics of Complex Traits in Drosophila melanogaster
Determining the genetic architecture of complex traits is challenging because phenotypic variation arises from interactions between multiple, environmentally sensitive alleles. We quantifiedExpand
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Epistasis and quantitative traits: using model organisms to study gene–gene interactions
  • T. Mackay
  • Biology, Medicine
  • Nature Reviews Genetics
  • 2014
The role of epistasis in the genetic architecture of quantitative traits is controversial, despite the biological plausibility that nonlinear molecular interactions underpin the genotype–phenotypeExpand
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The mutation rates of di-, tri- and tetranucleotide repeats in Drosophila melanogaster.
In a recent study, we reported that the combined average mutation rate of 10 di-, 6 tri-, and 8 tetranucleotide repeats in Drosophila melanogaster was 6.3 x 10(-6) mutations per locus per generation,Expand
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Low mutation rates of microsatellite loci in Drosophila melanogaster
Analysis of variation at microsatellite DNA loci is widely used in studies of parentage1, linkage2 and evolutionary history3–5. The utility of microsatel I ites is primarily due to high levels ofExpand
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Quantitative trait loci in Drosophila
  • T. Mackay
  • Biology, Medicine
  • Nature Reviews Genetics
  • 2001
Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traitsExpand
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