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- Publications
- Influence
Finding the missing heritability of complex diseases
- T. Manolio, F. Collins, +24 authors P. Visscher
- Biology, Medicine
- Nature
- 8 October 2009
Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture.… Expand
The Drosophila melanogaster Genetic Reference Panel
- T. Mackay, S. Richards, +49 authors R. Gibbs
- Biology, Medicine
- Nature
- 8 February 2012
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to… Expand
Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines.
- W. Huang, Andreas Massouras, +48 authors T. Mackay
- Biology, Medicine
- Genome research
- 1 July 2014
The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic… Expand
The genetic architecture of quantitative traits.
- T. Mackay
- Biology, Medicine
- Annual review of genetics
- 1 December 2001
Phenotypic variation for quantitative traits results from the segregation of alleles at multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and external… Expand
The genetics of quantitative traits: challenges and prospects
- T. Mackay, E. Stone, J. Ayroles
- Biology, Medicine
- Nature Reviews Genetics
- 1 August 2009
A major challenge in current biology is to understand the genetic basis of variation for quantitative traits. We review the principles of quantitative trait locus mapping and summarize insights about… Expand
Systems Genetics of Complex Traits in Drosophila melanogaster
- J. Ayroles, M. A. Carbone, +8 authors T. Mackay
- Biology, Medicine
- Nature Genetics
- 27 January 2009
Determining the genetic architecture of complex traits is challenging because phenotypic variation arises from interactions between multiple, environmentally sensitive alleles. We quantified… Expand
Epistasis and quantitative traits: using model organisms to study gene–gene interactions
- T. Mackay
- Biology, Medicine
- Nature Reviews Genetics
- 2014
The role of epistasis in the genetic architecture of quantitative traits is controversial, despite the biological plausibility that nonlinear molecular interactions underpin the genotype–phenotype… Expand
The mutation rates of di-, tri- and tetranucleotide repeats in Drosophila melanogaster.
- M. Schug, C. Hutter, K. Wetterstrand, M. Gaudette, T. Mackay, C. Aquadro
- Biology, Medicine
- Molecular biology and evolution
- 1 December 1998
In a recent study, we reported that the combined average mutation rate of 10 di-, 6 tri-, and 8 tetranucleotide repeats in Drosophila melanogaster was 6.3 x 10(-6) mutations per locus per generation,… Expand
Low mutation rates of microsatellite loci in Drosophila melanogaster
- M. Schug, T. Mackay, C. Aquadro
- Biology, Medicine
- Nature Genetics
- 1997
Analysis of variation at microsatellite DNA loci is widely used in studies of parentage1, linkage2 and evolutionary history3–5. The utility of microsatel I ites is primarily due to high levels of… Expand
Quantitative trait loci in Drosophila
- T. Mackay
- Biology, Medicine
- Nature Reviews Genetics
- 2001
Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits… Expand
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