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Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b.
HBeAg loss after treatment with PEG-IFN alpha-2b alone or in combination with lamivudine is sustained in the majority of patients and is associated with a high likelihood of HBsAg loss, particularly in genotype A-infected patients. Expand
Genetic polymorphism of alcohol dehydrogenase in europeans: TheADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1
The ADH 2*2 allele decreases the risk for alcoholism, whereas the ADH2*2 and ADH3*1 alleles are found to be associated in the European population. Expand
Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gastric mucosal lesions and mechanism of protection against oxidative stress - induced gastric injury.
Gastric mucosa, exposed to stress conditions, exhibits an enhancement of lipid peroxidation (increase of MDA and 4-HNE), as well as a decrease of SOD activity and GSH concentration, which appears to be an essential mechanism for understanding the pathogenesis of stress - induced functional disturbances in the gastric mucoso leading to ulcerogenesis. Expand
Inflammatory bowel disease: epidemiology, pathology and risk factors for hypercoagulability.
It has been demonstrated that there is a significant decrease of tissue plasminogen activator level, a marked increase of plasmine activator inhibitor type 1 and thrombin-activable fibrinolysis inhibitor, and a significantly lower level of antithrombin III and tissue factor pathway inhibitor. Expand
Effect of Candida colonization on human ulcerative colitis and the healing of inflammatory changes of the colon in the experimental model of colitis ulcerosa.
It is concluded that Candida delays healing of UC in both humans and that induced by TNBS in rats, and antifungal therapy and probiotic treatment during Candida infection could be beneficial in the restoration and healing of colonic damage in UC. Expand
The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract
This review was designed to provide an update in recent research on the involvement of IAP in intestinal inflammatory processes with focus on IBD in experimental animal models and human patients. Expand
The brain-gut axis in irritable bowel syndrome--clinical aspects.
  • T. Mach
  • Medicine
  • Medical science monitor : international medical…
  • 3 June 2004
The current approach to IBS patients is based on a positive diagnosis of the symptom complex, exclusion of underlying organic disease, and institution of a therapeutic trial, which includes visceral analgesics and serotonin agonists and antagonists. Expand
Diet and nutritional factors in inflammatory bowel diseases.
There is no single common diet suitable for all IBD patients; each of them is unique and dietary recommendations must be individually developed for each patient, depending on the course of the disease, past surgical procedures and type of pharmacotherapy. Expand
Biological therapy of inflammatory bowel disease.
Biological therapy is a promising option because it enables to withdraw corticosteroids and immunosuppressive agents or to reduce their dose, and it shortens the hospital stay, allows to avoid surgical procedures, extends the remission period and improves patients' quality of life. Expand
Can exercise affect the course of inflammatory bowel disease? Experimental and clinical evidence.
An overview of the effects of exercise on human and experimental colitis in animal models that mimic human disease is provided, although the information on exercise in human IBD are sparse and poorly understood. Expand