• Publications
  • Influence
Effect of genistein and quercetin on proliferation, collagen synthesis, and type I procollagen mRNA levels of rat hepatic stellate cells.
TLDR
GE and QU inhibited hepatic stellate cell proliferation and collagen synthesis that might have a protective role against liver fibrosis and type I procollagen mRNA level.
Mechanism of inhibition of platelet aggregation by HCL-31D.
TLDR
Data indicate that HCL-31D is an inhibitor of phosphodiesterase and that its antiplatelet effect is mainly mediated by elevation of cyclic AMP levels.
Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta pro-osteoclastic activities.
TLDR
Quercetin exerted a marked inhibitory effect on TNF and IL-1 activities, related to their pro-osteoclastic function, and this effect was limited to tumor necrosis factor and interleukin-1 beta activities.
Antimicrobial activity of synthetic all-D mastoparan M.
TLDR
Findings indicated the all-D mastoparan M could kill bacteria by disrupting cells by showing strong activity against gram-positive and gram-negative bacteria.
[Antifibrotic effects of genistein and quercetin in vitro].
TLDR
GE and quercetin may have therapeutic potential against liver fibrosis by regulating PDGF and TGF beta 1 actions.
[Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries].
TLDR
It is suggested that PKC inhibitors H-7 and quercetin protect BPAEC from TNF induced injuries and PKC play an important role in EC activation by TNF.
The cytolytic action of all-D mastoparan M on tumor cell lines.
  • T. M. Wu, M. L. Li
  • Chemistry, Medicine
    International journal of tissue reactions
  • 1999
TLDR
All-D and all-L mastoparan M, a tetradecapeptide toxin from hornet venom, were chemically synthesized in this study and appeared to inhibit the growth of tumor cells by direct lysis of target cells.
Stimulation of TNF-alpha, IL-1beta and nitrite release from mouse cultured spleen cells and lavaged peritoneal cells by mastoparan M.
TLDR
Results suggest that modulation of both neutrophil and macrophage influx by mastoparan M may be conveyed through TNF-alpha and IL-1beta secretion accompanied by nitrite formation.
Inhibitory effect of hexapeptide (RGRHGD) on platelet aggregation.
TLDR
Data indicate that the inhibitory effect of RGRHGD on platelet aggregation may be due to the attenuation of thromboxane A2 formation and intracellular calcium mobilization, and may provide a useful method of finding potential therapeutic agents by using molecular modeling analysis.
Protein kinase C inhibitor H-7 blocks effects of tumor necrosis factor on bone cells.
TLDR
TNF has potent effects on the osteoblasts, and the blockade of TNF actions by H-7 suggests that TNF exerts its effects through PK C.