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Levonorgestrel-releasing IUD as a method of contraception with therapeutic properties.
TLDR
The levonorgestrel-releasing intrauterine device LNg IUD is a new contraceptive method that combines the advantages of both hormonal and intrauterines contraception and can be used as an effective therapy for menorrhagia.
Protective Effect of Intrauterine Release of Levonorgestrel on Pelvic Infection: Three Years' Comparative Experience of Levonorgestrel- and Copper-Releasing Intrauterine Devices
TLDR
For the first time, a protective effect of the levonorgestrel IUD against pelvic inflammatory disease as compared with the Nova-T was seen statistically, and may help to solve one of the major concerns associated with intrauterine contraception.
Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes.
TLDR
These studies demonstrate that certain progestins in common clinical use probably possess inherent glucocorticoid activity and suggest that side effects attributable to this character might be expected when these compounds are used in pharmacological doses.
Pharmacokinetics and metabolism of RU 486.
TLDR
High concentrations of circulating metabolites capable of binding to the progesterone receptor suggest a significant contribution of these steroids in the overall antiprogestational action.
TISSUE CONCENTRATIONS OF LEVONORGESTREL IN WOMEN USING A LEVONORGESTREL‐RELEASING IUD
TLDR
In vitro experiments showed a rapid uptake of levonorgestrel and an unsaturability of the fat tissue by the steroid at the concentrations used, which correlated with the plasma concentrations.
Endometrial Morphology During Long‐Term Use of Levonorgestrel‐Releasing Intrauterine Devices
TLDR
Intrauterine release of Levonorgestrel resulted in endo-metrial glandular atrophy and decidualized stroma and inflammation and necrosis were seen as local signs of IUD use.
Therapeutic effects of the levonorgestrel-releasing intrauterine system in the treatment of idiopathic menorrhagia.
TLDR
The significant reduction of MBL and the increase in hemoglobin and serum ferritin levels in the treatment of menorrhagia with the LNG-IUS has great implications for women's reproductive health, particularly in developing countries.
Plasma concentrations and receptor binding of RU 486 and its metabolites in humans.
TLDR
Interestingly, the relative binding affinities of the metabolites studied to the human glucocorticoid receptor exceeded those of dexamethasone or cortisol, and indicate that the pool of certain metabolites of RU 486 may contribute to a significant extent to the antiprogestagenic (23-33%) and even greater extent toThe antiglucocortioid (47-61%) effects of RU486.
INTRAUTERINE CONTRACEPTION WITH LEVONORGESTREL: A COMPARATIVE RANDOMISED CLINICAL PERFORMANCE STUDY
Two levonorgestrel-releasing intrauterine devices (IUD) with different release rates of levonorgestrel and a 'Nova-T' copper-releasing device were compared in a randomised clinical performance study.
Effective contraception with the levonorgestrel-releasing intrauterine device: 12-month report of a European multicenter study.
TLDR
The results show that the Lng-IUD was ahighly effective contraceptive method which reduced menstrual bleeding and is a promising alternative for women desiring a highly effective method for long-term use.
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