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Gastric bypass reduces fat intake and preference.
TLDR
It is suggested that changes in fat preference may contribute to long-term maintained weight loss after gastric bypass and the role of GLP-1 in mediating postprandial responses after Gastric bypass requires further investigation.
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Overview of Animal Models of Obesity
The focus of this overview is on the animal models of obesity most commonly utilized in research. The models include monogenic models in the leptin pathway, polygenic diet‐dependent models, and, in…
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Amylin: Pharmacology, Physiology, and Clinical Potential
TLDR
Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol and is used clinically to treat type 1 and type 2 diabetes.
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Peptide YY Directly Inhibits Ghrelin-Activated Neurons of the Arcuate Nucleus and Reverses Fasting-Induced c-Fos Expression
TLDR
It is suggested that PYY may contribute to signaling a positive status of energy intake by inhibiting Arc neurons, which are activated under a negative status ofenergy intake by signals such as ghrelin.
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Effects of high carbohydrate and high fat diet on plasma metabolite levels and on iv glucose tolerance test in intact and neutered male cats
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Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet
TLDR
These data suggest that TLR2 is a molecular link between increased dietary lipid intake and the regulation of glucose homeostasis, via regulation of energy substrate utilisation and tissue inflammation.
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The role of amylin in the control of energy homeostasis.
  • T. Lutz
  • Biology
    American journal of physiology. Regulatory…
  • 1 June 2010
TLDR
Animal data, but also clinical data in humans, indicate that amylin is a promising candidate for the treatment of obesity; effects are most pronounced when amyl in is combined with leptin and chronic infusion of an amylIn receptor antagonist into the brain reduces body weight gain and adiposity.
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Roux-en-Y gastric bypass surgery reduces bone mineral density and induces metabolic acidosis in rats.
TLDR
It is suggested that initial calcium malabsorption may play a key role in bone loss early after RYGB in rats, but other factors, including chronic metabolic acidosis, contribute to insufficient bone restoration after normalization of intestinal calcium absorption.
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Evaluation of a novel real-time continuous glucose-monitoring system for use in cats.
TLDR
Although some readings substantially deviated from reference values, the CGMS yields reproducible results, is clinically accurate in cats with hyperglycemia and euglycemia, and is slightly less accurate if blood glucose concentrations are low.
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The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis.
TLDR
Data provide the first evidence that feeding-induced amylin release activates AP neurons projecting to subsequent relay stations known to transmit meal-related signals to the forebrain, and Activation of this pathway seems to coincide with an inhibition of LHA neurons.
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