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The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria.
TLDR
It is shown that Mge1 interacts with Ssq1 in an ATP-dependent manner, suggesting that M ge1 also regulates S sq1 function, which is an essential protein that mediates the import of nuclear-encoded proteins into the organelle and their subsequent folding. Expand
Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions
TLDR
It is concluded that Mia40 is the first essential component of a specific translocation pathway of metal‐binding IMS proteins that is able to bind zinc and copper ions. Expand
Import of small Tim proteins into the mitochondrial intermembrane space
TLDR
An import pathway is proposed in which Tim13 can pass through the TOM complex into and out of the IMS in an unfolded conformation, and cofactor acquisition stabilizes folding on the trans side of the outer membrane and traps Tim13 in the I MS, and drives unidirectional movement of the protein across the outer membranes of mitochondria. Expand
A non-essential function for yeast frataxin in iron-sulfur cluster assembly.
TLDR
Analysis of the incorporation of Fe-S clusters into yeast ferredoxin imported into isolated energized mitochondria from cells grown in the presence of glycerol, an obligatory respiratory carbon source, shows that frataxin is not essential forFe-S protein assembly, but improves the efficiency of the process. Expand
CHD6 is a DNA‐dependent ATPase and localizes at nuclear sites of mRNA synthesis
TLDR
It is reported that CHD6 is expressed in cells of human origin and in various mouse tissues, and it is demonstrated that it colocalizes with both hypo‐ and hyperphosphorlylated forms of RNA polymerase II. Expand
CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection
TLDR
The CHD6 association with inactive chromatin could be part of a process where the influenza virus triggers modifications of chromatin‐associated proteins that could contribute to the pathogenic events used by the virus to induce host cell shut‐off. Expand
Synthesis and characterization of a new class of inhibitors of membrane-associated UDP-glycosyltransferases.
TLDR
A new class of compounds designed to inhibit membrane-associated glycosyltransferases were synthesized and their biological activities were characterized in liver microsomes and human lymphoma cell lines, showing competitive inhibition of Glc-P-Dol synthase activity and photolabeling. Expand
Deletion of the Chd6 exon 12 affects motor coordination
TLDR
The genomic location, expression pattern, and ataxic phenotype of Chd6 Exon 12 −/− mice indicate that mutations within CHD6 may be responsible for one of these ataxias. Expand
123I-iodobenzoylglucosamines: Glucose analogues for heart imaging†
The ortho-, meta- and para-[123I]-2-deoxy-2-N-(iodobenzoyl)-D-glucosamine (BGA) derivatives were investigated to determine the effect of iodine position and lipophilicity on tissue distribution.Expand
Expression of trimeric human dUTP pyrophosphatase in Escherichia coli and purification of the enzyme.
TLDR
The ability to purify human dUTPase from E. coli should allow further characterization of the enzyme and provide material for the screening of potentially useful inhibitors, and the results of gel filtration experiments are consistent with a homotrimeric subunit composition for d UTPase. Expand
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