Novel ω-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes*
- R. Lewis, K. Nielsen, P. Alewood
- BiologyJournal of Biological Chemistry
- 10 November 2000
In electrophysiological studies, ω-conotoxins CVID and MVIIA had similar potencies to inhibit current through central and peripheral splice variants of the rat N-type calcium channels when coexpressed with rat β3 in Xenopus oocytes, but the potency of CVID increased when α1B-d and α1b-b were expressed in the absence of ratβ3.
Ion selectivity, transport properties and dynamics of amphotericin B channels studied over a wide range of acidity changes.
- Alina Asandei, T. Luchian
- BiologyColloids and Surfaces B: Biointerfaces
- 15 November 2008
Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
- S. Ko, Eunji Park, Yoonkyung Park
- Biology, ChemistryScientific Reports
- 23 June 2020
The results suggest that melectin has antibacterial activity and anti-inflammatory activity.
The role of Lys147 in the interaction between MPSA-gold nanoparticles and the α-hemolysin nanopore.
- Elisa J. Campos, Alina Asandei, Y. Astier
- 24 October 2012
This work provides evidence that Lys147 of α-hemolysin can interact with the sulfonate groups at the nanoparticle surface, and these interactions can reversibly block 100% of the residual ionic current.
Low dose X –ray effects on catalase activity in animal tissue
- R. Focea, C. Nădejde, D. Creanga, T. Luchian
- Physics, Biology
- 10 December 2012
The resulted balance of the two concurrent processes indicates the cell ability of decomposing the hydrogen peroxide-with benefits for the cell physiology restoration for the chosen low dose radiation.
Electroosmotic Trap Against the Electrophoretic Force Near a Protein Nanopore Reveals Peptide Dynamics During Capture and Translocation.
- Alina Asandei, Irina Schiopu, M. Chinappi, C. Seo, Yoonkyung Park, T. Luchian
- Biology, ChemistryACS Applied Materials and Interfaces
- 16 May 2016
The kinetic analysis of a peptide fluctuating between various microstates inside the nanopore enabled a detailed picture of the free energy description of its interaction with the α-HL nanopore, and when studied at the limit of vanishingly low transmembrane potentials, this provided a thermodynamic description of peptide reversible binding to and within the β-barrel domain.
Slowing down single-molecule trafficking through a protein nanopore reveals intermediates for peptide translocation
- L. Mereuta, M. Roy, T. Luchian
- Biology, ChemistryScientific Reports
- 27 January 2014
It is demonstrated how peptide passage through the α-hemolysin protein can be sufficiently slowed down to observe intermediate single-peptide sub-states associated to distinct structural milestones along the pore and how to control residence time, direction and the sequence of spatio-temporal state-to-state dynamics of a single peptide.
Phlorizin- and 6-ketocholestanol-mediated antagonistic modulation of alamethicin activity in phospholipid planar membranes.
- T. Luchian, L. Mereuta
- 1 September 2006
This study emphasizes the possibility that, by manipulating at will the sign of change and the magnitude of the interfacial dipole field, it is possible to modulate the extent of the membrane penetration of ion-channel-forming peptides and thereby provide deeper insights into mechanisms of protein-lipid and protein-protein interactions within membranes.
Kinetics of a reversible covalent-bond-forming reaction observed at the single-molecule level.
- Seong-Ho Shin, T. Luchian, S. Cheley, O. Braha, H. Bayley
- ChemistryAngewandte Chemie
- 4 October 2002
Antimicrobial Peptide CMA3 Derived from the CA-MA Hybrid Peptide: Antibacterial and Anti-inflammatory Activities with Low Cytotoxicity and Mechanism of Action in Escherichia coli
- Jong-kook Lee, C. Seo, T. Luchian, Yoonkyung Park
- BiologyAntimicrobial Agents and Chemotherapy
- 9 November 2015
It is suggested that CMA3 is an antimicrobial/antiendotoxin peptide that could serve as the basis for the development of anti-inflammatory and/or antimicrobial agents with low cytotoxicity.