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In-feed antibiotic effects on the swine intestinal microbiome
- T. Looft, T. Johnson, T. Stanton
- Biology, MedicineProceedings of the National Academy of Sciences
- 17 January 2012
Analysis of the metagenomes showed that microbial functional genes relating to energy production and conversion were increased in the antibiotic-fed pigs and that antibiotic resistance genes increased in abundance and diversity in the medicated swine microbiome despite a high background of resistance genes in nonmedication swine.
Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations
The collateral effects on the microbiota of antibiotic-fed animals caused divergence from that of control animals, with notable changes being increases in Escherichia coli populations in the ileum, Lachnobacterium spp.
Antibiotics in Feed Induce Prophages in Swine Fecal Microbiomes
Comparative metagenomics shows that prophages are induced by in-feed antibiotics in swine fecal microbiomes and that antibiotic resistance genes were detected in most viromes, suggesting that in- feed antibiotics are contributing to phage-mediated gene transfer, potentially of antibiotic resistant genes, in the swine gut.
Treatment, promotion, commotion: antibiotic alternatives in food-producing animals.
Clusters of Antibiotic Resistance Genes Enriched Together Stay Together in Swine Agriculture
Assessment of the scale of animal agriculture and its wastes, the enrichment and horizontal gene transfer potential of the clusters, and the vicinity of large human populations suggest that managing this resistance reservoir is important for minimizing human risk.
Butyrate-Producing Bacteria, Including Mucin Degraders, from the Swine Intestinal Tract
- U. Levine, T. Looft, H. Allen, T. Stanton
- BiologyApplied and Environmental Microbiology
- 12 April 2013
Three of the isolates grew on mucin, suggesting an intimate association with host intestinal mucosa, and butyryl coenzyme A (CoA):acetate CoA transferase activity, are associated with gut health problems.
Finding alternatives to antibiotics
- H. Allen, J. Trachsel, T. Looft, T. A. Casey
- Medicine, BiologyAnnals of the New York Academy of Sciences
- 1 September 2014
The spread of antibiotic‐resistant pathogens requires new treatments. As the rate of development of new antibiotics has severely declined, alternatives to antibiotics must be considered in both…
Collateral effects of antibiotics on mammalian gut microbiomes
The varied effects of antibiotics on human and animal microbiotas are explored, including the stimulation of gene transfer among gut bacteria and the reduction of immune responses in peripheral organs.
Carbadox has both temporary and lasting effects on the swine gut microbiota
In-feed carbadox caused striking effects within 4 days of administration, with significant alterations in both community structure and bacterial membership, notably a large relative increase in Prevotella populations in medicated pigs.
Cloacibacillus porcorum sp. nov., a mucin-degrading bacterium from the swine intestinal tract and emended description of the genus Cloacibacillus
A novel anaerobic, mesophilic, amino-acid-fermenting bacterium, isolated from the swine intestinal tract on mucin-based media, and it is proposed that strain CL-84T represents a novel species of the genus Cloacibacillus.