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The Molecular Taxonomy of Primary Prostate Cancer
View on Elsevier
Mixed Hyperplastic Adenomatous Polyps/Serrated Adenomas: A Distinct Form of Colorectal Neoplasia
TLDR
The clinicopathologic characteristics of 110 colorectal mixed hyperplastic adenomatous polyps (MHAP) are presented and it is suggested that these lesions reflect a morphologically unique variant of adenoma and be termed “serrated adenomas” in order to emphasize their neoplastic nature.
View on Wolters Kluwer
Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers
TLDR
Women with UPSC and CC of the uterus have a significantly poorer prognosis compared to those with G3EC, and more favourable histology (G3EC), younger age, and earlier stage were independent predictors of improved survival.
View on Springer
Ovarian Serous Tumors of Low Malignant Potential (Borderline Tumors): Outcome-Based Study of 276 Patients With Long-Term (≥5-Year) Follow-Up
TLDR
The small, but significant risk of progression over time to low-grade serous carcinoma emphasizes the need for prolonged follow-up in patients with S-LMP and the need to stratified into clinically benign and malignant groups.
View on Wolters Kluwer
Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus. A clinicopathologic study of 55 cases.
TLDR
It is proposed that APAs with markedly complex glands (high architectural index) be designated "atypical polypoid adenomyofibromas of low malignant potential" (APA-LMP) to emphasize the potential risk for myometrial invasion.
View on PubMed
Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.
View on PubMed
Estrogen receptor-negative invasive breast cancer: imaging features of tumors with and without human epidermal growth factor receptor type 2 overexpression.
TLDR
Biologic diversity of cancers may manifest in imaging characteristics, and, conversely, studying the range of imaging features of cancers May help refine current molecular phenotypes.
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Gene expression patterns in ovarian carcinomas.
TLDR
Although estrogen receptor was expressed in both the ovarian and breast cancers, genes that are coregulated with the estrogen receptor in breast cancers did not show a similar pattern of coexpression in the ovarian cancers.
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Endometrial Stromal Tumors: The New WHO Classification
TLDR
The clinicopathologic features of endometrial stromal tumors are presented; their immunophenotype is discussed; and the recent advances in molecular genetics which explain their pathogenesis and lend support for a new classification system are highlighted.
View on Wolters Kluwer
Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility
TLDR
A timeline of definitive germ cell differentiation from ESCs in vitro that initially parallels endogenous oocyte development in vivo is demonstrated by single-cell expression profiling and analysis of functional milestones including responsiveness to defined maturation media, shared genetic requirement of Dazl, and entry into meiosis.
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