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Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone
AgRP neuron activity drives feeding and weight gain whereas that of nearby POMC neurons does the opposite. However, the role of excitatory glutamatergic input in controlling these neurons is unknown.… Expand
Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.
- Eric D. Berglund, C. Liu, +7 authors J. Elmquist
- Biology, Medicine
- The Journal of clinical investigation
- 2 December 2013
Energy and glucose homeostasis are regulated by central serotonin 2C receptors. These receptors are attractive pharmacological targets for the treatment of obesity; however, the identity of the… Expand
IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α
Brown fat can reduce obesity through the dissipation of calories as heat. Control of thermogenic gene expression occurs via the induction of various coactivators, most notably PGC-1α. In contrast,… Expand
Hepatocyte Toll-like Receptor 4 Regulates Obesity-Induced Inflammation and Insulin Resistance
Chronic low-grade inflammation is a hallmark of obesity and thought to contribute to the development of obesity-related insulin resistance. Toll-like receptor 4 (Tlr4) is a key mediator of… Expand
Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin★
The hormone ghrelin stimulates eating and helps maintain blood glucose upon caloric restriction. While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of… Expand
Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis.
The molecular mechanisms underlying neuronal leptin and insulin resistance in obesity and diabetes remain unclear. Here we show that induction of the unfolded protein response transcription factor… Expand
Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons
Objective Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation – including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related… Expand
Non-alcoholic fatty liver disease is associated with progression of arterial stiffness.
- N. Li, G. Zhang, +4 authors R. Wang
- Nutrition, metabolism, and cardiovascular…
- 1 February 2015
BACKGROUND AND AIMS NAFLD is an independent risk factor for increased cardiovascular disease. Arterial stiffness is an index of subclinical atherosclerosis. The aims of this study were to examine… Expand
Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons
Melanocortin 4 receptors (MC4Rs) in the central nervous system are key regulators of energy and glucose homeostasis. Notably, obese patients with MC4R mutations are hyperinsulinemic and resistant to… Expand
TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons.
The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient… Expand