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Molecular Serum Markers of Liver Fibrosis
Fibrosis is a hallmark histologic event of chronic liver diseases and is characterized by the excessive accumulation and reorganization of the extracellular matrix (ECM). The gold standard for… Expand
Identification of novel recurrent CPSF6-RARG fusions in acute myeloid leukemia resembling acute promyelocytic leukemia.
TO THE EDITOR: Retinoic acid receptor γ (RARG) is a member of the nuclear receptor superfamily and shares high homology (90%) with retinoic acid receptor α (RARA) and retinoic acid receptor β… Expand
ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice.
BACKGROUND & AIMS Activation of transforming growth factor beta (TGFB) promotes liver fibrosis by activating hepatic stellate cells (HSCs), but the mechanism of TGFB activation are not clear. We… Expand
Fev regulates hematopoietic stem cell development via ERK signaling.
Reprogramming of somatic cells to desired cell types holds great promise in regenerative medicine. However, production of transplantable hematopoietic stem cells (HSCs) in vitro by defined factors… Expand
The Clinical Significance of GP73 in Immunologically Mediated Chronic Liver Diseases: Experimental Data and Literature Review
There is significant void in establishing validated non-invasive surrogate biomarkers of liver fibrosis/cirrhosis in chronic liver diseases (CLD). Golgi protein 73 (GP73) has been suggested as a… Expand
Integrated analysis of microRNA and gene expression profiles reveals a functional regulatory module associated with liver fibrosis.
BACKGROUND Liver fibrosis, characterized with the excessive accumulation of extracellular matrix (ECM) proteins, represents the final common pathway of chronic liver inflammation. Ever-increasing… Expand
Six-dimensional quantum dynamics study for the dissociative adsorption of HCl on Au(111) surface.
The six-dimensional quantum dynamics calculations for the dissociative chemisorption of HCl on Au(111) are carried out using the time-dependent wave-packet approach, based on an accurate PES which… Expand
HBV promotes the proliferation of hepatic stellate cells via the PDGF-B/PDGFR-β signaling pathway in vitro.
- Qixuan Bai, J. An, +5 authors J. Jia
- Biology, Medicine
- International journal of molecular medicine
- 1 December 2012
The activation of hepatic stellate cells (HSCs) is closely associated with liver fibrosis in chronic hepatitis B virus (HBV) infection. However, the molecular mechanisms… Expand
The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism
- T. Liu, P. Wang, M. Cong, You-qing Xu, J. Jia, H. You
- Biology, Medicine
- Bioscience reports
- 12 April 2013
DDC (diethyldithiocarbamate) could block collagen synthesis in HSC (hepatic stellate cells) through the inhibition of ROS (reactive oxygen species) derived from hepatocyte CYP2E1 (cytochrome P450… Expand
One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging
Highly cross-linked and monodispersed polyphosphazene nanoparticles (NPs) exhibiting strong fluorescence were prepared by a remarkably simple one-pot polycondensation of hexachlorocyclotriphosphazene… Expand