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Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
RationaleSchizophrenia is characterized by disturbances in sensorimotor gating and attentional processes, which can be measured by prepulse inhibition (PPI) and latent inhibition (LI), respectively.Expand
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Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1‐targeted mice
The GTF2IRD1 general transcription factor is a candidate for involvement in the varied cognitive and neurobehavioral symptoms of the microdeletion disorder, Williams–Beuren syndrome (WBS). We showExpand
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Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia
RationaleSchizophrenic patients demonstrate prominent negative and cognitive symptoms that are poorly responsive to antipsychotic treatment. Abnormal glutamatergic neurotransmission may contribute toExpand
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Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice
The menopausal transition in human females, which is driven by a loss of cyclic ovarian function, occurs around age 50 and is thought to underlie the emergence of an array of health problems in agingExpand
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Beta N‐acetylglucosaminyltransferase V (Mgat5) deficiency reduces the depression‐like phenotype in mice
The central nervous system (CNS) is rich in glycoconjugates, located on cell surface and in extracellular matrix. The products of Golgi UDP‐GlcNAc:N‐acetylglucosaminyltransferases (encoded by Mgat1,Expand
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Self-directed exploration provides a Ncs1-dependent learning bonus
Understanding the mechanisms of memory formation is fundamental to establishing optimal educational practices and restoring cognitive function in brain disease. Here, we show for the first time in aExpand
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Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes
In a dominant genetic screen for late‐onset motor impairments in mice, 16–20‐week‐old N‐nitroso‐N‐ethylurea (ENU)‐mutagenized females were subjected to a behavioural test battery consisting of aExpand
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Changes in brain serotonergic activity in anxious losers
Previous experiments showed that repeated experience of defeats in ten daily agonistic confrontations produced pronounced anxiety in C57BL/6J male mice (losers) as estimated by some plus-mazeExpand
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Drug Discovery for
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