Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling
- M. Jarosz, M. Olbert, Gabriela Wyszogrodzka, K. Młyniec, T. Librowski
- Biology, ChemistryInflammoPharmacology
- 12 January 2017
In vitro studies have shown that zinc decreases NF-κB activation and its target genes, such as TNF-α and IL-1β, and increases the gene expression of A20 and PPAR-α, the two zinc finger proteins with anti-inflammatory properties.
L-carnitine--metabolic functions and meaning in humans life.
It is suggested that continued studies are required before L-carnitine administration could be recommended as a routine procedure in the noted disorders, and further research is warranted in order to evaluate the biochemical, pharmacological, and physiological determinants of the response to carnitine supplementation.
Enhancement of antidepressant-like activity by joint administration of imipramine and magnesium in the forced swim test: Behavioral and pharmacokinetic studies in mice
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level.
- A. Grzywacz, J. Gdula-Argasińska, B. Muszyńska, M. Tyszka-Czochara, T. Librowski, W. Opoka
- BiologyActa Biochimica Polonica
- 3 September 2015
Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
Antidepressant-like effects of ketamine, norketamine and dehydronorketamine in forced swim test: Role of activity at NMDA receptor
An overview of the pharmacological properties and potential applications of natural monoterpenes.
- Agata Kozioł, Agnieszka Stryjewska, S. Lochyński
- Chemistry, BiologyMini-Reviews in Medical Chemistry
- 30 November 2014
These interesting activities of monoterpenes which might be potentially used not only in pharmaceutical, but also food and cosmetic industries are discussed below.
Transient receptor potential channels - emerging novel drug targets for the treatment of pain.
One of the most relevant strategies in the search for novel analgesic drugs is presented, namely the TRP channels and their ligands, both agonists and antagonists as potential novel therapeutics for inflammatory and neuropathic pain syndromes.
Omega-3 Fatty Acids and their Role in Central Nervous System - A Review.
- T. Wysoczański, Ewa Sokoła-Wysoczańska, T. Librowski
- MedicineCurrent medicinal chemistry
- 29 February 2016
Omega-3 PUFAs may act as therapeutic agents as well and their significant role against inflammatory diseases, such as cardiovascular and neurodegenerative diseases, has been described.
Polymer-based non-viral gene delivery as a concept for the treatment of cancer.
Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission