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Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling
In vitro studies have shown that zinc decreases NF-κB activation and its target genes, such as TNF-α and IL-1β, and increases the gene expression of A20 and PPAR-α, the two zinc finger proteins with anti-inflammatory properties. Expand
Enhancement of antidepressant-like activity by joint administration of imipramine and magnesium in the forced swim test: Behavioral and pharmacokinetic studies in mice
The data suggest that pharmacodynamic rather than pharmacokinetic interaction between magnesium and IMI is accountable for behavioral effect in the FST, and indicate the particular role of magnesium in the antidepressant action. Expand
L-carnitine--metabolic functions and meaning in humans life.
It is suggested that continued studies are required before L-carnitine administration could be recommended as a routine procedure in the noted disorders, and further research is warranted in order to evaluate the biochemical, pharmacological, and physiological determinants of the response to carnitine supplementation. Expand
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level.
Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders. Expand
Antidepressant-like effects of ketamine, norketamine and dehydronorketamine in forced swim test: Role of activity at NMDA receptor
It is demonstrated that ketamine and norketamines but not dehydronorketamine given acutely at subanesthetic doses reduced immobility in the forced swim test, appearing attributable to NMDA receptor inhibition. Expand
Comparison of the Psychopharmacological Effects of Tiletamine and Ketamine in Rodents
It is suggested that TIL could be an alternative to KET as an antidepressant with an additional anxiolytic-like profile, as are their adverse effect liabilities. Expand
Transient receptor potential channels - emerging novel drug targets for the treatment of pain.
One of the most relevant strategies in the search for novel analgesic drugs is presented, namely the TRP channels and their ligands, both agonists and antagonists as potential novel therapeutics for inflammatory and neuropathic pain syndromes. Expand
Strong antioxidant activity of carane derivatives.
This study examined the antioxidant activity of carane derivatives--KP-23 and its optical isomers--that possess strong local anesthetic and anti-inflammatory activity and found thatCarane derivatives serve as potent antioxidants by scavenging radicals. Expand
Synthesis and preliminary anti-inflammatory evaluation of xanthone derivatives
Abstract Xanthone derivatives of acetic, propionic and 2-methylpropionic acids were synthesized and assayed for their anti-inflammatory, analgesic and ulcerogenic activities. Compound 8 causes aExpand
Antidepressant‐like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents
Investigation of the antidepressant‐like activity of the selective GABAB receptor antagonists CGP 36742 and CGP 51176 and a selective agonist CGP 44532 in models of depression in rats and mice finds limited data to support this proposition. Expand