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High-efficiency TALEN-based gene editing produces disease-resistant rice
volume 30 number 5 may 2012 nature biotechnology 24 repeat units for recognition of a specific set of 24 contiguous nucleotides at the target sites (Supplementary Fig. 1). For each pair of TALEN… Expand
Breast cancer intrinsic subtype classification, clinical use and future trends.
Breast cancer is composed of multiple subtypes with distinct morphologies and clinical implications. The advent of microarrays has led to a new paradigm in deciphering breast cancer heterogeneity,… Expand
MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN.
Multidrug resistance (MDR) is the major cause of failure of gastric cancer chemotherapy. Members of the miR-17-92 cluster, including miR-19a/b, are considered oncomiRs and influence multiple aspects… Expand
miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression
Although it is well established that embryonic stem (ES) cells have the potential to differentiate into dopamine neurons, the molecular basis of this process, particularly the role of microRNAs… Expand
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes
Breast cancer is a complex disease encompassing multiple tumor entities, each characterized by distinct morphology, behavior and clinical implications. Besides estrogen receptor, progesterone… Expand
ABCG15 encodes an ABC transporter protein, and is essential for post-meiotic anther and pollen exine development in rice.
In flowering plants, anther and pollen development is critical for male reproductive success. The anther cuticle and pollen exine play an essential role, and in many cereals, such as rice,… Expand
Inhibitory effects of microRNA 19b in hepatic stellate cell‐mediated fibrogenesis
Hepatic stellate cell (HSC) activation is a pivotal event in initiation and progression of hepatic fibrosis and a major contributor to collagen deposition driven by transforming growth factor beta… Expand
TALEN-Mediated Homologous Recombination Produces Site-Directed DNA Base Change and Herbicide-Resistant Rice.
- T. Li, B. Liu, C. Chen, B. Yang
- Medicine, Biology
- Journal of genetics and genomics = Yi chuan xue…
- 20 May 2016
Over the last decades, much endeavor has been made to advance genome editing technology due to its promising role in both basic and synthetic biology. The breakthrough has been made in recent years… Expand
Prevalence of Coccidial Infection in Dairy Cattle in Shanghai, China
Abstract: The prevalence of coccidial infections in dairy cattle was examined in Shanghai from November 2010 to March 2011. In total, 626 fecal samples from 24 dairy farms were examined; oocysts were… Expand
CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis.
Closely located at the tumor suppressor locus 16q22.1, CKLF-like MARVEL transmembrane domain-containing member 3 and 4 (CMTM3 and CMTM4) encode two CMTM family proteins, which link chemokines and the… Expand