• Publications
  • Influence
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
TLDR
(R,S)-4-phosphonophenylglycine (PPG) is described as a novel, potent, and selective agonist for group III mGluRs and protected against N-methyl-D-aspartate- and quinolinic acid-induced striatal lesions in rats and was anticonvulsive in the maximal electroshock model in mice. Expand
Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective
TLDR
Results indicate that mGlu5 receptors represent a suitable target for novel neuroprotective agents of potential application in neurodegenerative disorders. Expand
A Novel Splice Variant of a Metabotropic Glutamate Receptor, Human mGluR7b
TLDR
Northern blot analysis indicate that mGluR7 expression is developmentally regulated and is expressed at high levels in human fetal brain and at a lower level in many regions of adult human brain. Expand
Selective Activation of mGlu4 Metabotropic Glutamate Receptors Is Protective against Excitotoxic Neuronal Death
TLDR
Microdialysis studies showed that intrastriatal infusion of NMDA increased extracellular glutamate levels to a greater extent in −/− than in +/+ mice, supporting the hypothesis that the mGluR4 subtype is necessary for the maintenance of the homeostasis of extrace cellular glutamate levels. Expand
Experimental absence seizures: potential role of gamma-hydroxybutyric acid and GABAB receptors.
TLDR
All effects of R(-)-baclofen are mediated by the GABAB receptor, whereas only the induction of SWD by GHB is dependent on GABABceptor mediation, the decrease in cGMP being only partially so, and these results indicate that GABAB receptors are of primary importance in experimental absence epilepsy and that GABAb receptor antagonists may represent a new class of anti-absence drugs. Expand
Experimental absence seizures: potential role of γ-hydroxybutyric acid and GABAB receptors
We have investigated whether the pathogenesis of spontaneous generalized non-convulsive seizures in rats with genetic absence epilepsy is due to an increase in the brain levels of γ-hydroxybutyricExpand
Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4
TLDR
Northern blot analyses indicate that hmGluR4 is strongly expressed in the cerebellum of the adult human brain but also at low levels in hippocampus, hypothalamus and thalamus. Expand
Effects of selective dopamine D1 and D2 receptor agonists on the rate of GABA synthesis in mouse brain.
TLDR
Stimulation of D2 receptors induces a decrease in the rate of GABA formation in the four brain areas examined, whereas stimulation of D1 receptors either increases GABA synthesis in the corpus striatum or does not alter it, which appears to be independent of the degree of receptor occupancy. Expand
[Interactions of GABAergic and catecholaminergic neurotransmissions. Effects of dopaminergic and noradrenergic agonists and antagonists on GABA turnover].
TLDR
The tonic inhibition exerted by DA on GABA-mediated neurotransmission seems to be mainly controlled by D2 receptors. Expand
Reversal by apomorphine of the gabaculine-induced GABA accumulation in mouse cortex.
TLDR
Results showed that inhibition of GABA-T by gabaculine is a sensitive and reliable method for the estimation of the rate of synthesis. Expand
...
1
2
...