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The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
TLDR
PPARalpha is a critical regulator of myocardial fatty acid uptake and utilization, activation of cardiac PPARalpha regulatory pathways results in a reciprocal repression of glucose uptake and usage pathways, and derangements in myocardian energy metabolism typical of the diabetic heart can become maladaptive, leading to cardiomyopathy. Expand
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
TLDR
It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life. Expand
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
TLDR
It is demonstrated that the expression of lipin 1 is induced by peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha), a transcriptional coactivators controlling several key hepatic metabolic pathways. Expand
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders.
TLDR
A critical role for PPAR alpha is defined in a transcriptional regulatory response to fasting and the PPARalpha-/- mouse is identified as a potentially useful murine model of inborn and acquired abnormalities of human fatty acid utilization. Expand
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.
TLDR
It is concluded that P GC-1alpha and PGC-1beta share roles that collectively are necessary for the postnatal metabolic and functional maturation of heart and BAT. Expand
Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth.
TLDR
Results indicate that during cardiac hypertrophic growth, PPARalpha is deactivated at several levels, leading to diminished capacity for myocardial lipid and energy homeostasis. Expand
Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
TLDR
It is demonstrated that the expression of lipin 1 is induced by peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha), a transcriptional coactivators controlling several key hepatic metabolic pathways. Expand
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
TLDR
This study is the first to demonstrate that induction of adult-like metabolism has a critical role in establishing an adult-onset disease model using patient-specific iPSCs, and revealed crucial pathogenic insights that metabolic derangement in adult- like metabolic milieu underlies ARVD/C pathologies, enabling us to propose novel disease-modifying therapeutic strategies. Expand
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
TLDR
The present findings suggest a novel paradigm for dietary fatty acids in the pathogenesis of alcoholic liver disease and provide a promising therapeutic strategy—nutritional modulation of adiponectin—in treating human alcoholic fatty liver disease. Expand
The Failing Heart Relies on Ketone Bodies as a Fuel
TLDR
It is shown that the hypertrophied and failing heart shifts to ketone bodies as a significant fuel source for oxidative ATP production, and whether this fuel shift is adaptive or maladaptive could unveil new therapeutic strategies for heart failure. Expand
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