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Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic.
TLDR
This work discusses how C(10)-based formulations are being tested for oral delivery of bisphosphonates using Gastro Intestinal Permeation Enhancement Technology, GIPET and in a related solid dose format for antisense oligonucleotides (ISIS Pharmaceuticals, USA).
Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET).
TLDR
A summary of some approaches taken to intestinal permeation enhancement is presented and the oral delivery system developed by Merrion Pharmaceuticals, Gastrointestinal Permeation Enhancement Technology (GIPET) is explored.
Relief of Hot Flushes With New Plant-Derived 10-Component Synthetic Conjugated Estrogens
TLDR
The 0.3-mg, 0.625-mg and 1.25-mg dose strengths of 10-component synthetic conjugated estrogen significantly reduced the frequency and severity of vasomotor symptoms compared with placebo, and were well tolerated during this 12-week study.
Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET™
TLDR
Using fluxes of markers of epithelial permeability, the effects of GIPET on the human intestine were shown to be rapid, short-lived and reversible in vivo, suggesting that GIPet formulations have genuine potential as a platform technology for safe and effective oral drug delivery of a wide range of poorly permeable drugs.
Oral administration of the GnRH antagonist acyline, in a GIPET®-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics
TLDR
Oral administration of GIPET®-enhanced acyline significantly suppresses testosterone and gonadotropins in normal men without untoward side effects and might have utility in the management of prostate cancer.
Kinetic implications of drug resorption from the bladder.
TLDR
The mechanism of action of these metabolites is still poorly understood, but the basic idea that they can be a source of irritation to the lining of the bladder is supported.
MER-101-03, a multicenter, phase II study to compare MER-101 20mg tablets to intravenous zoledronic acid 4mg in prostate cancer patients.
TLDR
Orazol weekly therapy appears to be as effective as Zometa, based on the biomarkers analyzed, and a rapid decrease for all four biomarkers was seen at seven days, and was sustained throughout the study.
Oral-Absorption-Enhancing Drug-Delivery Technology
Intestinal-absorption enhancers to improve the oral delivery of poorly permeable drug compounds have been studied since the 1960s. The approaches taken to increase absorption of these types of
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