T. Lehmann

Publications28
h-index8
Citations244
Highly Influential Citations7
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Effects of enzymatically inactive recombinant botulinum neurotoxin type A at the mouse neuromuscular junctions.
Botulinum neurotoxin A (BoNT/A) is used clinically to treat several neurological and metabolic diseases. However, the mechanisms that underlie the clinical use of the toxin remain still to be… Expand
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Impact of ionic strength on partitioning of naphthenic acids in water–crude oil systems – Determination through high-field NMR spectroscopy
Abstract Naphthenic acids and asphaltenes are two classes of materials indigenous to crude oils that are recognized as potential emulsion stabilizers. Reduction in interfacial tension and formation… Expand
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Novel Curcumin Derivative CNB-001 Mitigates Obesity-Associated Insulin Resistance
Type 2 diabetes is growing at epidemic proportions, and pharmacological interventions are being actively sought. This study examined the effect of a novel neuroprotective curcuminoid, CNB-001… Expand
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NMR studies of the paramagnetic complex Fe(II)-bleomycin.
The coordination chemistry of the iron(II) complex of the antitumor drug bleomycin has been extensively investigated with a number of spectroscopic and chemical techniques. However, the actual… Expand
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NMR study of peplomycin in aqueous solution. Assignment of resonances by means of two-dimensional spectroscopy
1H-NMR spectra of peplomycin (PEP) recorded at 400 and, for the first time, 900 MHz at 2 °C were examined. All the spin systems in the PEP molecule were identified through 2D NMR spectroscopy. The… Expand
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Interaction of Zn(II)bleomycin-A2 and Zn(II)peplomycin with a DNA hairpin containing the 5′-GT-3′ binding site in comparison with the 5′-GC-3′ binding site studied by NMR spectroscopy
Bleomycins are a group of glycopeptide antibiotics synthesized by Streptomyces verticillus that are widely used for the treatment of various neoplastic diseases. These antibiotics have the ability to… Expand
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Coordination chemistry of co(II)-bleomycin: its investigation through NMR and molecular dynamics.
Previous studies on the coordination chemistry of Co-bleomycin have suggested the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively,… Expand
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Molecular modeling of the three-dimensional structure of Fe(II)-bleomycin: are the Co(II) and Fe(II) adducts isostructural?
  • T. Lehmann
  • Chemistry, Medicine
  • JBIC Journal of Biological Inorganic Chemistry
  • 1 March 2002
Abstract. The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with… Expand
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Possible structural role of the disaccharide unit in Fe-bleomycin before and after oxygen activation
Our previous investigation of the solution structure of Fe(II)-bleomycin pointed toward the carbamoyl group in the mannose moiety or a water molecule as possible alternative axial ligands to the… Expand
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Effects of asphaltenes and organic acids on crude oil-brine interfacial visco-elasticity and oil recovery in low-salinity waterflooding
Abstract Smart-water flooding has become increasingly more important as Enhanced-Oil Recovery technology in recent years. However, the observed incremental recovery varies significantly from case to… Expand
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