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Effects of enzymatically inactive recombinant botulinum neurotoxin type A at the mouse neuromuscular junctions.
Botulinum neurotoxin A (BoNT/A) is used clinically to treat several neurological and metabolic diseases. However, the mechanisms that underlie the clinical use of the toxin remain still to beExpand
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Impact of ionic strength on partitioning of naphthenic acids in water–crude oil systems – Determination through high-field NMR spectroscopy
Abstract Naphthenic acids and asphaltenes are two classes of materials indigenous to crude oils that are recognized as potential emulsion stabilizers. Reduction in interfacial tension and formationExpand
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Novel Curcumin Derivative CNB-001 Mitigates Obesity-Associated Insulin Resistance
Type 2 diabetes is growing at epidemic proportions, and pharmacological interventions are being actively sought. This study examined the effect of a novel neuroprotective curcuminoid, CNB-001Expand
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NMR studies of the paramagnetic complex Fe(II)-bleomycin.
The coordination chemistry of the iron(II) complex of the antitumor drug bleomycin has been extensively investigated with a number of spectroscopic and chemical techniques. However, the actualExpand
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NMR study of peplomycin in aqueous solution. Assignment of resonances by means of two-dimensional spectroscopy
1H-NMR spectra of peplomycin (PEP) recorded at 400 and, for the first time, 900 MHz at 2 °C were examined. All the spin systems in the PEP molecule were identified through 2D NMR spectroscopy. TheExpand
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Interaction of Zn(II)bleomycin-A2 and Zn(II)peplomycin with a DNA hairpin containing the 5′-GT-3′ binding site in comparison with the 5′-GC-3′ binding site studied by NMR spectroscopy
Bleomycins are a group of glycopeptide antibiotics synthesized by Streptomyces verticillus that are widely used for the treatment of various neoplastic diseases. These antibiotics have the ability toExpand
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Coordination chemistry of co(II)-bleomycin: its investigation through NMR and molecular dynamics.
Previous studies on the coordination chemistry of Co-bleomycin have suggested the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively,Expand
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Molecular modeling of the three-dimensional structure of Fe(II)-bleomycin: are the Co(II) and Fe(II) adducts isostructural?
  • T. Lehmann
  • Chemistry, Medicine
  • JBIC Journal of Biological Inorganic Chemistry
  • 1 March 2002
Abstract. The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, withExpand
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Possible structural role of the disaccharide unit in Fe-bleomycin before and after oxygen activation
Our previous investigation of the solution structure of Fe(II)-bleomycin pointed toward the carbamoyl group in the mannose moiety or a water molecule as possible alternative axial ligands to theExpand
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Effects of asphaltenes and organic acids on crude oil-brine interfacial visco-elasticity and oil recovery in low-salinity waterflooding
Abstract Smart-water flooding has become increasingly more important as Enhanced-Oil Recovery technology in recent years. However, the observed incremental recovery varies significantly from case toExpand
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