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Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.
TLDR
The macrophage enzyme is immunologically induced at the transcriptional level and closely resembles the enzyme in cytokine-treated tumor cells and inflammatory neutrophils. Expand
P-type calcium channels blocked by the spider toxin omega-Aga-IVA.
TLDR
A peptide toxin from funnel web spider venom, omega-Aga-IVA, is identified, which is a potent inhibitor of both calcium entry into rat brain synaptosomes and of 'P-type' calcium channels in rat Purkinje neurons, which will facilitate characterization of brain calcium channels resistant to existing channel blockers and may assist in the design of neuroprotective drugs. Expand
Gallinacins: cysteine‐rich antimicrobial peptides of chicken leukocytes
TLDR
Gallinacins showed primary sequence homology to the recently delineated β‐ defensin family, suggesting that β‐defensins originated at least 250 million years ago, before avian and mammalian lineages diverged. Expand
Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae.
TLDR
This work purified the yeast U5 and U6 pre-mRNA splicing small nuclear ribonucleoproteins by affinity chromatography and analyzed the associated polypeptides by mass spectrometry, showing that, unlike the human tri- snRNP, the yeast tri-snRNP dissociated upon addition of ATP or dATP. Expand
Purification, identification, concentration and bioactivity of (Z)-7-dodecen-1-yl acetate: sex pheromone of the female Asian elephant, Elephas maximus.
TLDR
The remarkable convergent evolution of this compound suggests that compounds identified in mammalian exudates that are also present in pheromone blends of insects should be re-evaluated as potential mammalian chemosignals. Expand
Calmodulin is a subunit of nitric oxide synthase from macrophages
TLDR
It is shown that macrophage NOS contains, as a tightly bound subunit, a molecule with the immunologic reactivity, high performance liquid chromatography retention time, tryptic map, partial amino acid sequence, and exact molecular mass of CaM. Expand
Primary structure of a cardioactive neuropeptide from the tobacco hawkmoth, Manduca sexta
TLDR
The amino acid sequence of the first of a family of insect cardioregulatory peptides from the tobacco hawkmoth, Manduca sexta, has been determined using a combination of Edman degradation microsequencing and mass spectroscopy and it is proposed that this peptide be named Manduca CCAP. Expand
Characterization of Two Novel Neuropeptides From the Sea Cucumber Holothuria glaberrima.
TLDR
Sequence similarities between GFSKLYFamide, SGYSVLYfamide, and a pair of peptides previously isolated from starfish lead us to propose that all four molecules are members of a family of peptide acting as neurotransmitters in echinoderms. Expand
Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor.
TLDR
Diazepam effects a stimulation of adrenal mitochondrial cholesterol delivery similar to that observed for endozepine, suggesting that the mediation of corticotropin-induced steroidogenesis may be the physiological function of the peripheral-type benzodiazepine receptor. Expand
Isolation and sequence of an active-site peptide containing a catalytic aspartic acid from two Streptococcus sobrinus alpha-glucosyltransferases.
TLDR
The peptide segment is highly conserved and homologous to a peptide from sucrase-isomaltase labeled by site-directed irreversible inhibition and peptide segments common to a broad array of alpha-glucosidases and related transferases. Expand
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