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A national review of vertical HIV transmission
Objectives:Prevention of vertical HIV transmission has evolved significantly in Canada over the last two decades. The aim of this analysis is to describe the surveillance programme used, rate of… Expand
Acute kidney injury reduces the hepatic metabolism of midazolam in critically ill patients
AbstractIntroductionAcute kidney injury (AKI) is a common and serious complication increasing morbidity and mortality from all causes of hospital admission. We have previously shown that AKI… Expand
Validating a self-confidence scale for surgical trainees.
OBJECTIVE Self-confidence is a feeling of trust in one's abilities, qualities, and judgement. It is one of the cognitive mechanisms underlying behavioural change. Variations in self-confidence… Expand
Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study
AbstractAimTo examine the effect of walking before dinner on 24-h glycemic control in individuals with type 2 diabetes using the standardized multi-site Exercise-Physical Activity and Diabetes… Expand
Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine
IntroductionCardiac troponins are sensitive and specific biomarkers of myocardial necrosis. We evaluated troponin, CK, and ECG abnormalities in patients with septic shock and compared the effect of… Expand
Attainment of Recommended Lipid Targets in Patients With Familial Hypercholesterolemia: Real-World Experience With PCSK9 Inhibitors.
- Omar Razek, Lubormira Cermakova, +5 authors L. Brunham
- The Canadian journal of cardiology
- 1 August 2018
BACKGROUND Familial hypercholesterolemia (FH) is the most common inherited dyslipidemia and is characterized by elevated low-density lipoprotein cholesterol (LDL-C) and markedly increased risk for… Expand
Evolution and Impact of a Regional Reperfusion System for ST-Elevation Myocardial Infarction.
BACKGROUND We describe the evolution of a regional system designed to provide primary percutaneous coronary intervention (pPCI) as the preferred method of revascularization for ST-elevation… Expand
Using midazolam to monitor changes in hepatic drug metabolism in critically ill patients
- Christopher John Kirwan, T. Lee, David W. Holt, R. Michael Grounds, Iain A. M. MacPhee, Barbara J. Philips
- Intensive Care Medicine
- 7 February 2009
ObjectiveCritical illness and associated sequelae can cause severe metabolic disturbances. The effects these have on hepatic drug metabolism are poorly understood. In vivo, enzyme specific drug… Expand
Teaching Vaginal Surgery to Junior Residents: Initial Validation of 3 Novel Procedure-Specific Low-Fidelity Models.
OBJECTIVE Competency-based surgical education relies on operative models to teach surgical skills within a curriculum. Low fidelity simulation has been shown to improve surgical performance. Our… Expand
Do labetalol and methyldopa have different effects on pregnancy outcome? Analysis of data from the Control of Hypertension In Pregnancy Study (CHIPS) trial
- L. Magee, P. Dadelszen, +18 authors J-M Moutquin
- BJOG : an international journal of obstetrics and…
- 1 June 2016
To compare pregnancy outcomes, accounting for allocated group, between methyldopa‐treated and labetalol‐treated women in the CHIPS Trial (ISRCTN 71416914) of ‘less tight’ versus ‘tight’ control of… Expand