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Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
- G. Davies, N. Armstrong, +125 authors I. Deary
- Psychology, Medicine
- Molecular Psychiatry
- 1 February 2015
General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and… Expand
An UNC-40 pathway directs postsynaptic membrane extension in Caenorhabditis elegans
The postsynaptic membrane of the embryonic neuromuscular junction undergoes a dramatic expansion during later development to facilitate the depolarization of larger muscles. In C. elegans, the… Expand
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT… Expand
Clinical assessment of social cognitive function in neurological disorders
- J. Henry, W. Hippel, Pascal Molenberghs, T. Lee, P. Sachdev
- Psychology, Medicine
- Nature Reviews Neurology
Social cognition broadly refers to the processing of social information in the brain that underlies abilities such as the detection of others' emotions and responding appropriately to these emotions.… Expand
Effects of Temporal Lobe Epilepsy on Retrograde Memory
Summary: Purpose: In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine… Expand
RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.
ABT-737 is a promising chemotherapeutic agent that promotes apoptosis by acting as a selective BH3 mimetic to neutralize Bcl-2-like family members. One shortcoming with its use is that Mcl-1, a… Expand
Recent trends in testing social cognition
Purpose of review Social cognition refers broadly to the way in which we process social information, and is a critical predictor of social competency. This article provides an overview of some of the… Expand
A review of different methods of assessing social cognitive function in clinical settings.
- J. Henry, David G Cowan, T. Lee, P. Sachdev
- Medicine, Psychology
- Current opinion in psychiatry
- 1 March 2015
PURPOSE OF REVIEW Social cognition refers broadly to the way in which we process social information, and is a critical predictor of social competency. This article provides an overview of some of the… Expand
Association of HLA-DRw4 with rheumatoid arthritis in black and white patients.
The HLA-A, B, C, and DR antigens were typed in 35 black and 35 white Americans with rheumatoid arthritis. The frequency of HLA-DRw4 was increased in both the black and white patient patient groups… Expand
HLA serological cross-reactivity: HLA-B15 has two public antigens.
On the basis of their serologic cross-reactivity, HLA antigens can be organized into cross-reactive groups or CREG's. We have recently defined immunochemically two public alloantigenic determinants X… Expand