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Proteome turnover in the green alga Ostreococcus tauri by time course 15N metabolic labeling mass spectrometry.
Protein synthesis and degradation determine the cellular levels of proteins, and their control hence enables organisms to respond to environmental change. Experimentally, these are little knownExpand
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Definition and characterization of a "trypsinosome" from specific peptide characteristics by nano-HPLC-MS/MS and in silico analysis of complex protein mixtures.
Although HPLC-ESI-MS/MS is rapidly becoming an indispensable tool for the analysis of peptides in complex mixtures, the sequence coverage it affords is often quite poor. Low protein expressionExpand
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The use of a novel quantitation strategy based on Reductive Isotopic Di-Ethylation (RIDE) to evaluate the effect of glufosinate on the unicellular algae Ostreococcus tauri.
We report a novel stable-isotope labeling strategy for quantitative proteomics analysis. The method consists of labeling N-termini and lysine ε-amino groups through reductive amination usingExpand
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Differential analysis of membrane proteins in mouse fore- and hindbrain using a label-free approach.
The ability to quantitatively compare protein levels across different regions of the brain to identify disease mechanisms remains a fundamental research challenge. It requires both a robust method toExpand
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Effect of the polar headgroup of phospholipids on their interaction with actin.
It is generally admitted that actin filaments are anchored to a membrane by membranar actin-binding-proteins. However, we found that actin may also interact directly with membrane phospholipids. TheExpand
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Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
We show here that the M2 isoform of human pyruvate kinase (M2PYK) is susceptible to nitrosation and oxidation, and that these modifications regulate enzyme activity by preventing the formation of theExpand
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  • Open Access