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Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo.
PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-kappaB to promoter and exerts a beneficial effect in the mouse model of sepsis and protects mice against LPS-induced lethal toxicity. Expand
Antimicrobial coatings: a remedy for medical device-related infections.
The mechanisms involved in the different approaches to antimicrobial coatings are discussed and a new application that seems to offer an antimicrobial surface that is effective for long-term medical implants and suitable for a variety of drugs is reported on. Expand
Thymic atrophy caused by ethanol in a mouse model for binge drinking: involvement of endogenous glucocorticoids.
It is suggested that a single dose of EtOH induces thymic atrophy which is predominantly mediated by increased levels of endogenous glucocorticoid levels which might have immunosuppressive effects. Expand
IRF-1-mediated CAS expression enhances interferon-gamma-induced apoptosis of HT-29 colon adenocarcinoma cells.
The results indicate that tumor cells highly expressing CAS may be more susceptible to apoptosis induced by reagents that are capable of inducing CAS expression, and may be a target for the elimination of tumors. Expand
Nandrolone decanoate reduces the premature mortality of cardiomyopathic hamsters.
Male hamsters of an inbred strain carrying a genetic trait for cardiomyopathy were dosed by sc injection weekly with an anabolic-androgenic steroid, nandrolone decanoate, beginning when 3 months old, and significantly prolonged survival of the hamsters. Expand