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Increase of adhesion molecules, fibrinogen, type‐1 plasminogen activator inhibitor and orosomucoid in growth hormone (GH) deficient adults and their modulation by recombinant human GH replacement
TLDR
Patients with GHD, like those with CVD, show an increase in fibrinogen, type‐1 plasminogen activator inhibitor (PAI‐1), acute phase response proteins (APR), and soluble adhesion molecules.
Ultrasonography of the uterus within 6 weeks following Cesarean section
TLDR
The aim of the study was to compare the integrity of the uterine scar after elective and urgent Caesarean section and specify a technique to describe the sonographic findings and quantify the severity of the scar defect.
Detection of apoptotic cells and expression of Ki‐67 antigen, Bcl‐2, p53 oncoproteins in human parathyroid adenoma
TLDR
It is suggested that parathyroid adenomas contain cell populations with proliferative activity (clonal proliferation), but the weak immunoreactive expression of p53 combined with the relatively strong expression of bcl‐2 might contribute to a slow glandular growth.
Rivaroxaban - Metabolism, Pharmacologic Properties and Drug Interactions.
TLDR
In comparison with low molecular weight heparin and fondaparinux requiring subcutaneous way of administration, and with vitamin K antagonists (VKAs), which require regular monitoring of international normalized ratio, rivaroxaban is relatively easy to use, however, adjustments of dose are needed in individuals with impaired renal functions.
Increasing plasma levels of soluble cell adhesion molecules (sE-Selectin, sP-Selectin and sICAM-1) in overweight adults with combined hyperlipidemia.
TLDR
Combined hyperlipidemia in adults with overweight is associated with elevated soluble plasma levels of CAMs, and levels in these patients may be determined as a marker for appreciation of their potential atherosclerotic burden.
[Prevalence of thrombophilic mutations of FV Leiden, prothrombin G20210A and PAl-1 4G/5G and their combinations in a group of 1450 healthy middle-aged individuals in the Prague and Central Bohemian
TLDR
The found frequencies of genotypes and alleles confirm a relatively high prevalence of hereditary thrombophilia in the Czech Republic.
[Guidelines of Czech Association for Thrombosis and Haemostasis of the Czech Medical Association of J. E. Purkyně for safety treatment with new oral anticoagulants (NOAC) - dabigatran etexilate,
TLDR
There are presently new oral anticoagulants (NOAC) for prevention and the treatment of thromboembolic diseases and they are registered in CZ with advantage of some properties not being seen in "classical" anticoAGulants.
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