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Metabolites from the Endophytic Fungus Nodulisporium sp. from Juniperus cedre
Seven new metabolites, 3-hydroxy-1-(2,6-dihydroxyphenyl)butan-1-one (1), 1-(2-hydroxy-6-methoxyphenyl)butan-1-one (3), 2,3-dihydro-5-methoxy-2-methylchromen-4-one (6), the dimeric naphthalenes
Three Diketopiperazine Alkaloids with Spirocyclic Skeletons and One Bisthiodiketopiperazine Derivative from the Mangrove-Derived Endophytic Fungus Penicillium brocae MA-231.
TLDR
Four new diketopiperazines including spirobrocazines A-C (1-3) and brocazine G (4) were characterized from the mangrove-derived Penicillium brocae MA-231 and exhibited potent cytotoxicity against both sensitive and cisplatin-resistant human ovarian cancer cells and strong antimicrobial activity against pathogenic Staphylococcus aureus.
Hybrid isoprenoids from a reeds rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64.
TLDR
Drimentines G (3) showed strong cytotoxicity against human cancer cells lines with IC(50)'s down to 1.01 μM, while 1 and 2 showed no significant activity.
An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins.
TLDR
An unprecedented enzymatic [4+2] cyclization cascade that has a central role in the biosynthesis of pyrroindomycins, which are pentacyclic spirotetramate natural products is reported and it is confirmed that homologs are functionally exchangeable.
New mono- and dimeric members of the secalonic acid family: blennolides A-G isolated from the fungus Blennoria sp.
TLDR
Seven unusual chromanones were isolated together with secalonic acid B from Blennoria sp.
Structure, absolute configuration, and conformational study of 12-membered macrolides from the fungus Dendrodochium sp. associated with the sea cucumber Holothuria nobilis Selenka.
TLDR
This is the first report of 12-membered macrolides from the fungus of the genus Dendrodochium and indicates the complexity of β-ketoreductase stereospecificity in the biosynthesis of enigmatic iterative fungal polyketides.
Versixanthones A-F, Cytotoxic Xanthone-Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009.
TLDR
Six unusual xanthone-chromanone dimers, versixanthones A-F (1-6), featuring different formal linkages of tetrahydroxanthone and 2,2-disubstituted chroman-4-one monomers, were isolated from a culture of the mangrove-derived fungus Aspergillus versicolor HDN1009 and exhibited cytotoxicities against the seven tested cancer cell lines.
Functional significance of five noncanonical Ca2+‐binding sites of human transglutaminase 2 characterized by site‐directed mutagenesis
TLDR
It can be concluded that five of the Ca2+‐binding sites of TG2 influence its transglutaminase activity, two sites are involved in the regulation of GTP enzyme activity, and one determines antigenicity for autoantibodies in celiac patients.
Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus
TLDR
A new dithiodiketopiperazine derivative possessing a unique spiro[furan-2,7'-pyrazino[1,2-b]oxazine] skeleton and compounds 1 and 2 showed inhibitory activity against the pathogenic fungus Alternaria brassicae.
Atropisomeric dihydroanthracenones as inhibitors of multiresistant Staphylococcus aureus.
TLDR
The compounds exhibited antibacterial activity against Staphylococcus aureus, including (multi)drug-resistant clinical isolates, and showed no cytotoxic activity, encouraging their further evaluation as potential starting points for antibacterial drug development.
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